Back to Search
Start Over
Nailfold videocapillaroscopy alterations in dermatomyositis, antisynthetase syndrome, overlap myositis, and immune-mediated necrotizing myopathy
- Source :
- Clinical Rheumatology, Clinical Rheumatology, Springer Verlag, 2019, 38 (12), pp.3451-3458. ⟨10.1007/s10067-019-04710-2⟩, Clinical Rheumatology, 2019, 38 (12), pp.3451-3458. ⟨10.1007/s10067-019-04710-2⟩
- Publication Year :
- 2019
-
Abstract
- The aim of our study was to investigate possible differences in nailfold videocapillaroscopy (NVC) features between patients with dermatomyositis (DM), overlap myositis (OM), antisynthetase syndrome (ASS), and immune-mediated necrotizing myopathy (IMNM).We performed a cross-sectional monocentric study. All patients with inflammatory myopathies (IMs) over a 6-month period were analyzed by NVC for giant and ramified capillaries, tortuosities, capillary density, disorganization, and scleroderma pattern. Clinical, biological, and pathological characteristics were retrospectively recorded. Patients were classified as having DM, OM, ASS, or IMNM for comparison. Patients were also compared with a group of patients with systemic sclerosis (SSc).NVC was analyzed in DM (n = 17), OM (n = 8), ASS (n = 12), and IMNM (n = 6). Vascular disorganization and avascular zones were observed only in DM (11.8%) and OM (62.5%). The percentage of patients with giant capillaries was higher in OM (n = 4/8) than in DM (n = 3/17) and absent in ASS and IMNM. Frequency of ramified capillaries, tortuosities, hemorrhages, or thrombosis was not different between subgroups. A scleroderma pattern was only observed in OM patients.In this limited series of patients, we observed that DM and OM NVC abnormalities are different from ASS and IMNM. We could not determine NVC specific patterns associated with myositis-specific antibody subtypes of DM because of the small number of patients.Key Points• Nailfold videocapillaroscopy abnormalities are different in subgroups of inflammatory myopathies.• Giant capillaries, disorganization, and major capillary loss are observed in overlap myositis and dermatomyositis but not in antisynthetase syndrome (ASS) or immune-mediated necrotizing myopathy.• Nailfold videocapillaroscopy abnormalities in overlap myositis (with the exclusion of ASS) are close to systemic sclerosis.
- Subjects :
- Male
[SDV]Life Sciences [q-bio]
Nailfold videocapillaroscopy
Antisynthetase syndrome
Gastroenterology
Immune-mediated necrotizing myopathy
Scleroderma
DISEASE
Microscopic Angioscopy
0302 clinical medicine
Medicine
ORGAN INVOLVEMENT
030212 general & internal medicine
Myositis
RAYNAUDS
MICROSCOPY
General Medicine
Middle Aged
Thrombosis
3. Good health
POLYMYOSITIS
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Female
Adult
medicine.medical_specialty
CAPILLARY ABNORMALITIES
Overlap myositis
CLASSIFICATION
Dermatomyositis
03 medical and health sciences
Rheumatology
Internal medicine
Humans
Pathological
Aged
030203 arthritis & rheumatology
business.industry
SYSTEMIC-SCLEROSIS
medicine.disease
Capillaries
Cross-Sectional Studies
Inflammatory myopathies
Nailfold capillaroscopy
PATTERNS
AUTOANTIBODIES
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- ISSN :
- 14349949 and 07703198
- Volume :
- 38
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Clinical rheumatology
- Accession number :
- edsair.doi.dedup.....6cbc8400850a02358f157b8747529356