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The cortical blood-brain barrier in multiple sclerosis: a gateway to progression?
- Publication Year :
- 2018
- Publisher :
- Springer, 2018.
-
Abstract
- Despite the historical focus on white matter pathology, it is now increasingly recognised that cortical tissue injury is critical to disease outcome. Cortical pathology occurs from the earliest disease stages, predominates in progressive MS, and correlates with physical and cognitive disability [1]. However, our understanding of disease processes operative in the MS cortex remains poor and, in particular, the contribution of BBB dysfunction has been relatively overlooked. A recent radiological study and pathological findings from our group make steps to address these shortcomings and provide fresh insight into the role of BBB dysfunction in cortical pathology.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Multiple Sclerosis
Neurology
Blood–brain barrier
Article
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Neuroradiology
Inflammation
medicine.diagnostic_test
business.industry
Multiple sclerosis
Disease progression
Magnetic resonance imaging
Gateway (computer program)
medicine.disease
Magnetic Resonance Imaging
030104 developmental biology
medicine.anatomical_structure
Blood-Brain Barrier
Disease Progression
Neurology (clinical)
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6cbeec7689aeebafc2cad1c040d96923