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Optimization and characterization of curcumin loaded in octenylsuccinate oat β-glucan micelles with an emphasis on degree of substitution and molecular weight
- Source :
- Journal of agricultural and food chemistry. 62(30)
- Publication Year :
- 2014
-
Abstract
- The dependence of the curcumin loading capacity (CLC) of octenylsuccinate oat β-glucan (OSG) micelles on the structural parameters (degree of substitution, DS; molecular weight, Mw) of OSG was unknown and explored in this study. Meanwhile, the curcumin-loaded OSG micelle (COM) was first characterized. The results from response surface methodology revealed that the linear effects of Mw and stirrer input power, as well as the quadratic effect of DS, were significant (p < 0.05). The maximum CLC value of the OSG micelle was obtained as 4.21 μg/mg. Dynamic light scattering showed that the average size and ζ potential of the COM were 308 nm and -10.8 mV, respectively. Transmission electron microscopy and atomic force microscopy evidenced that the COM was elliptical in shape. Fourier transform infrared spectroscopy, differential scanning calorimeltry, and X-ray diffraction revealed that curcumin was loaded in OSG micelles in an amorphous form by interacting with OSG molecules.
- Subjects :
- Curcumin
beta-Glucans
Chemistry
Hydrolysis
Analytical chemistry
General Chemistry
Microscopy, Atomic Force
Micelle
Molecular Weight
Dynamic light scattering
Microscopy, Electron, Transmission
X-Ray Diffraction
Transmission electron microscopy
Microscopy
X-ray crystallography
Spectroscopy, Fourier Transform Infrared
Molecule
Particle size
Fourier transform infrared spectroscopy
Particle Size
General Agricultural and Biological Sciences
Micelles
Subjects
Details
- ISSN :
- 15205118
- Volume :
- 62
- Issue :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of agricultural and food chemistry
- Accession number :
- edsair.doi.dedup.....6cbfbc295fc5eaaf480386a6aa92a936