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Resistin and visfatin: are they valuable enough to be the differential diagnosis in familial Mediterranean fever with acute appendicitis?
- Source :
- Clinical Rheumatology. 31:225-229
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Familial Mediterranean fever (FMF) is an autosomal recessive disease which predominantly affects certain ethnic groups mainly Sephardic Jews, Turks, Arabs, and Armenians. Differential diagnosis of an attack of FMF with appendicitis could be difficult in patients presenting with acute abdomen. Circulating levels of resistin and visfatin have been shown to increase in several inflammatory conditions. In this study we aimed to investigate the role of resistin and visfatin in diseases activity by monitoring these adipokines' levels in patients with FMF (attacks and attack-free period) and acute appendicitis. The study involves four groups: group 1-31 FMF patients at attack (M/F, 14/17), group 2-27 FMF patients at attack-free period (M/F, 9/18), group 3-29 acute appendicitis patients (M/F, 16/13), and group 4-20 healthy controls (M/F, 10/10). Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, fibrinogen, resistin, visfatin, interleukin-1β, interleukin-6, interleukin-10, TNF-α, and IFN-γ were evaluated concurrently. Resistin level could be a useful test in diagnosis of FMF patients in attacks period but not in acute appendicitis as differential diagnosis. Measuring visfatin levels would not give additional information neither for attacks and attack-free period nor FMF attack and appendicitis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Familial Mediterranean fever
Adipokine
Gastroenterology
Diagnosis, Differential
Rheumatology
Internal medicine
medicine
Humans
Resistin
Nicotinamide Phosphoribosyltransferase
medicine.diagnostic_test
Interleukin-6
business.industry
General Medicine
Appendicitis
medicine.disease
Familial Mediterranean Fever
Interleukin-10
C-Reactive Protein
Endocrinology
Acute abdomen
Erythrocyte sedimentation rate
Acute Disease
Female
medicine.symptom
Differential diagnosis
business
Subjects
Details
- ISSN :
- 14349949 and 07703198
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Clinical Rheumatology
- Accession number :
- edsair.doi.dedup.....6ccc9abb6eb1c0a50d5beee4fc71f386