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Additional file 6: of A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus

Authors :
Kumar, Dilip
Puan, Kia
Andiappan, Anand
Bernett Lee
Westerlaken, Geertje
Haase, Doreen
Melchiotti, Rossella
Li, Zhuang
Nurhashikin Yusof
Lum, Josephine
Koh, Geraldine
Shihui Foo
Yeong, Joe
Alexessander Alves
Pekkanen, Juha
Sun, Liang
Irwanto, Astrid
Fairfax, Benjamin
Naranbhai, Vivek
Common, John
Tang, Mark
Chuang, Chin
Marjo-Riitta Jarvelin
Knight, Julian
Xuejun Zhang
Fook Chew
Prabhakar, Shyam
Jianjun, Liu
Wang, De Yun
Zolezzi, Francesca
Poidinger, Michael
E. Lane
Meyaard, Linde
RĂśtzschke, Olaf
Publication Year :
2017
Publisher :
Figshare, 2017.

Abstract

In silico prediction of transcription factors with allele-specific binding to rs612529. The web based prediction tools JASPAR (A) and TRANSFAC (B) were used to identify potential transcription factor binding sites in the VSTM1 promoter region affected by the allelic variations of rs612529 T/C. Only sites predicted with a binding score greater than 5.0 (JASPAR) and 0.9 (TRANSFAC) were selected for further analysis. The nucleotide underlined in red indicates the location of rs612529 within binding motif of the respective TF. Yellow shaded rows indicate transcription factors predicted to be highly specific for T allele.5. (PDF 55Â kb)

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....6ccd4b63c74c114b53ac926b579b1c1d
Full Text :
https://doi.org/10.6084/m9.figshare.c.3696271_d1.v1