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Strong and Reversible Covalent Double Network Hydrogel Based on ForceāCoupled Enzymatic Reactions
- Source :
- Angewandte Chemie International Edition. 61
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- Biological load-bearing tissues are strong, tough, and recoverable under periodic mechanical loads. However, such features have rarely been achieved simultaneously in the same synthetic hydrogels. Here, we use a force-coupled enzymatic reaction to tune a strong covalent peptide linkage to a reversible bond. Based on this concept we engineered double network hydrogels that combine high mechanical strength and reversible mechanical recovery in the same hydrogels. Specifically, we found that a peptide ligase, sortase A, can promote the proteolysis of peptides under force. The peptide bond can be re-ligated by the same enzyme in the absence of force. This allows the sacrificial network in the double-network hydrogels to be ruptured and rebuilt reversibly. Our results demonstrate a general approach for precisely controlling the mechanical and dynamic properties of hydrogels at the molecular level.
- Subjects :
- Hydrogels
General Medicine
General Chemistry
Peptides
Catalysis
Mechanical Phenomena
Subjects
Details
- ISSN :
- 15213773 and 14337851
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi.dedup.....6ceb39e793ed0267dac6d5e07cbb5ad7