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Is Partial or Total Thyroidectomy Associated with Risk of Long-Term Osteoporosis: A Nationwide Population-Based Study
- Source :
- World Journal of Surgery. 42:2864-2871
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Whether thyroidectomy contributes to osteoporosis (OP) and osteoporotic fracture (OF) is a subject of debate. This study aimed to determine the effect of thyroidectomy on the risk of OP and OF. This retrospective cohort study is based on patient data between January 2000 to December 2005 from the National Health Insurance Research Database. Patients who underwent thyroidectomy were enrolled in the thyroidectomy cohort, and the control cohort was selected by propensity score matching at a ratio of 1:4. Incident OP and OF cases were identified until the end of 2013. The thyroidectomy cohort to control cohort adjusted hazard ratio (aHR) for OP/OF was assessed through multivariable Cox proportional hazard regression analysis. Totals of 1426 and 5704 patients were included in the thyroidectomy and control cohorts, respectively. The incidence density of OP was higher in the thyroidectomy cohort (7.91/1000 person-years) than in the control cohort (5.98/1000 person-years), with an aHR of 1.43 (95% CI 1.16–1.77, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Databases, Factual
medicine.medical_treatment
Taiwan
030209 endocrinology & metabolism
Comorbidity
Cohort Studies
Young Adult
03 medical and health sciences
0302 clinical medicine
Bone Density
Risk Factors
Internal medicine
medicine
Humans
Postoperative Period
Propensity Score
Aged
Proportional Hazards Models
Retrospective Studies
business.industry
Proportional hazards model
Incidence
Incidence (epidemiology)
Hazard ratio
Thyroidectomy
Retrospective cohort study
Middle Aged
Thyroid Diseases
Research Design
Propensity score matching
Cohort
Osteoporosis
Female
Surgery
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 14322323 and 03642313
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- World Journal of Surgery
- Accession number :
- edsair.doi.dedup.....6cef038ed973d5e775c362fabff35da0