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Interleukin-6 and Interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic–clonic seizures
- Source :
- Epilepsy Research. 41:205-211
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- We have previously reported increased concentrations of interleukin (1L)-6 in CSF from patients with tonic-clonic seizures, where increased cytokine production most likely is a consequence of neuronal epileptic activity associated with seizures. The biological effects of IL-6 are mediated by other cytokines, which are studied here in addition to IL-6. The purpose of this study was to analyze levels of soluble cytokines from plasma and CSF from patients with newly developed tonic-clonic seizures. The concentrations of IL-6, IL-1 receptor antagonist (IL-1RA), IL-1beta, tumor necrosis factor (TNFalpha) and nerve growth factor (NGF) were measured from plasma and CSF from 22 patients with newly developed tonic-clonic seizures within 24 h from the seizure and 18 controls. The mean concentrations of IL-6 were significantly increased in CSF (P
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.drug_class
medicine.medical_treatment
Epilepsy
Cerebrospinal fluid
Internal medicine
Nerve Growth Factor
Humans
Medicine
Interleukin 6
biology
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Receptors, Interleukin-1
Interleukin
Middle Aged
Receptor antagonist
medicine.disease
Receptors, Interleukin-6
Cytokine
Nerve growth factor
Endocrinology
Interleukin 1 receptor antagonist
Neurology
Blood-Brain Barrier
biology.protein
Female
Epilepsy, Tonic-Clonic
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 09201211
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Epilepsy Research
- Accession number :
- edsair.doi.dedup.....6cf9316631f58712e0c7af2f1c8ad527