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Genetic dissection of drug resistance in trypanosomes
- Source :
- Parasitology
- Publication Year :
- 2013
- Publisher :
- Cambridge University Press, 2013.
-
Abstract
- SUMMARYThe trypanosomes cause two neglected tropical diseases, Chagas disease in the Americas and African trypanosomiasis in sub-Saharan Africa. Over recent years a raft of molecular tools have been developed enabling the genetic dissection of many aspects of trypanosome biology, including the mechanisms underlying resistance to some of the current clinical and veterinary drugs. This has led to the identification and characterization of key resistance determinants, including transporters for the anti-Trypanosoma bruceidrugs, melarsoprol, pentamidine and eflornithine, and the activator of nifurtimox-benznidazole, the anti-Trypanosoma cruzidrugs. More recently, advances in sequencing technology, combined with the development of RNA interference libraries in the clinically relevant bloodstream form ofT. bruceihave led to an exponential increase in the number of proteins known to interact either directly or indirectly with the anti-trypanosomal drugs. In this review, we discuss these findings and the technological developments that are set to further revolutionise our understanding of drug-trypanosome interactions. The new knowledge gained should inform the development of novel interventions against the devastating diseases caused by these parasites.
- Subjects :
- Veterinary Drugs
Trypanosoma cruzi
030231 tropical medicine
Trypanosoma brucei brucei
Melarsoprol
Computational biology
Drug resistance
03 medical and health sciences
0302 clinical medicine
RNA interference
Eflornithine
parasitic diseases
medicine
Animals
Humans
African trypanosomiasis
Chagas Disease
Trypanosoma brucei
030304 developmental biology
0303 health sciences
drug resistance
biology
Neglected Diseases
Sequence Analysis, DNA
biology.organism_classification
medicine.disease
Virology
Trypanocidal Agents
3. Good health
Infectious Diseases
Trypanosomiasis, African
Neglected tropical diseases
Animal Science and Zoology
Parasitology
Trypanosomiasis
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14698161 and 00311820
- Volume :
- 140
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Parasitology
- Accession number :
- edsair.doi.dedup.....6d02603781b3b7fd2549f01d46006d37