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Susceptibility trends of ceftolozane/tazobactam and comparators when tested against U.S. gram-negative bacterial surveillance isolates (2012-2018)
- Source :
- Diagnostic microbiology and infectious disease. 100(1)
- Publication Year :
- 2020
-
Abstract
- Ceftolozane/tazobactam is an antipseudomonal cephalosporin combined with a β-lactamase inhibitor. Ceftolozane/tazobactam has been approved in >60 countries for treating complicated urinary tract infections, acute pyelonephritis, complicated intra-abdominal infections (with metronidazole), and hospital-acquired pneumonia, including ventilator-associated pneumonia in adults. We analyzed susceptibilities for 35,882 gram-negative isolates collected from patients in 35 US medical centers from 2012 to 2018. The rate of multi-drug resistant Enterobacterales was stable (9.5%–10.1%), while the P. aeruginosa multi-drug resistance rate increased from 15.5% in 2012 to 22.9% in 2018. The carbapenem-resistant Enterobacterales rates varied from 0.9% to 2.2% and extended-spectrum β-lactamase phenotypes increased from 10.5% to 16.8%. The most active drugs against P. aeruginosa were ceftolozane/tazobactam (95.8%–97.5% susceptible) and amikacin (93.9%–98.0%); against Enterobacterales, amikacin (97.9%–98.8%), meropenem (97.7%–98.8%), and ceftolozane/tazobactam (93.3%–95.6%) were the most active. These data suggest that ceftolozane/tazobactam has effective in vitro activity against organisms causing serious gram-negative infections.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Tazobactam
medicine.drug_class
030106 microbiology
Cephalosporin
Microbial Sensitivity Tests
Gastroenterology
Meropenem
03 medical and health sciences
0302 clinical medicine
Internal medicine
Drug Resistance, Bacterial
Gram-Negative Bacteria
polycyclic compounds
medicine
Humans
Public Health Surveillance
030212 general & internal medicine
Gram
business.industry
General Medicine
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
medicine.disease
United States
Anti-Bacterial Agents
Cephalosporins
Metronidazole
Pneumonia
Infectious Diseases
Amikacin
Ceftolozane
business
Gram-Negative Bacterial Infections
medicine.drug
Subjects
Details
- ISSN :
- 18790070
- Volume :
- 100
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Diagnostic microbiology and infectious disease
- Accession number :
- edsair.doi.dedup.....6d042a6185ac16132240694a5f71ef39