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Brain-derived neurotrophic factor (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: a blinded retrospective multi-centric study
- Source :
- Journal of neurotrauma. 29(11)
- Publication Year :
- 2012
-
Abstract
- Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences neuronal plasticity throughout life. Emergence from a vegetative state (VS) after a traumatic brain injury (TBI) implies that the brain undergoes plastic changes. A common polymorphism in the BDNF gene—BDNF Val66Met (referred to herein as BDNFMet)—impairs cognitive function in healthy subjects. The aim of this study was to determine whether the BDNFMet polymorphism plays a role in the recovery of consciousness and cognitive functions in patients in a VS after a TBI. Fifty-three patients in a VS 1 month after a TBI were included in the study and genotyped for the BDNFMet polymorphism. Scores of levels of cognitive functioning (LCF) at 1, 3, 6, and 12 months post-TBI were retrospectively compared in patients without (Val group), and with (Met group), the BDNFMet polymorphism. The BDNFMet polymorphism was detected in 20 out of the 53 patients. The mean LCF scores in the Val and Met groups were 1.6 – 0.5 and 1.4 – 0.5 at 1 month, 2.3 – 0.7 and 2.5 – 1.2 at 3 months, 3.3 – 1.7 and 3.5 – 1.7 at 6 months, and 4 – 1.9 and 3.9 – 1.8 at 12 months, respectively ( p > 0.05). The percentages of patients in the Val and Met groups who emerged from the VS were 36.4% and 30% at 3 months, 66.3% and 70% at 6 months, and 70% and 87.5% at 12 months ( p > 0.05), respectively. These findings provide evidence that the BDNFMet polymorphism is not involved in cognitive improvement in patients with a VS following TBI. Future studies should focus on the role of other BDNF polymorphisms in the recovery from a VS.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
disorders of consciousne
Adolescent
Genotype
Traumatic brain injury
Polymorphism, Single Nucleotide
vegetative state
Young Adult
Neurotrophic factors
Internal medicine
Neuroplasticity
medicine
Humans
Young adult
Psychiatry
Retrospective Studies
Brain-derived neurotrophic factor
biology
traumatic brain injury
Brain-Derived Neurotrophic Factor
Persistent Vegetative State
levels of cognitive functioning
genetic factor
Retrospective cohort study
Cognition
Recovery of Function
Middle Aged
medicine.disease
nervous system
Brain Injuries
biology.protein
Female
Neurology (clinical)
Psychology
Polymorphism, Restriction Fragment Length
Neurotrophin
Subjects
Details
- ISSN :
- 15579042
- Volume :
- 29
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of neurotrauma
- Accession number :
- edsair.doi.dedup.....6d04cf30d9405d61227d572ff147cbad