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Risk of dementia in patients with primary insomnia: a nationwide population-based case-control study
- Source :
- BMC Psychiatry, BMC Psychiatry, Vol 18, Iss 1, Pp 1-7 (2018)
- Publication Year :
- 2018
- Publisher :
- BioMed Central, 2018.
-
Abstract
- Background To investigate the association between primary insomnia and dementia using a Taiwanese population-based database. Methods This case-control study involved a subset of Taiwan’s National Health Insurance Research Database of reimbursement claims. We included 51,734 patients who were diagnosed with primary insomnia from 2002 to 2004 as the test group and 258,715 nonprimary insomnia participants aged 20 years or older as the reference group. We excluded patients under 20 and those with depression, post-traumatic stress disorder, and/or sleep disorders caused by organic lesion(s), drugs, or alcohol. We used a Cox proportional hazards model to assess the primary insomnia on the risk of developing dementia after adjusting for sociodemographic characteristics and comorbidities. Results The primary insomnia cohort had a higher prevalence of diabetes, dyslipidemia, hypertension, coronary heart disease, chronic liver disease, and chronic kidney disease at baseline. After adjusting for select comorbidities, primary insomnia remained a significant predisposing factor for developing dementia, and was associated with a 2.14-fold (95% confidence interval, 2.01–2.29) increase in dementia risk. We also found a higher risk of dementia in younger patients. Conclusions Taiwanese patients with primary insomnia, especially those under 40, had a higher risk of developing dementia than those without primary insomnia.
- Subjects :
- Adult
Male
medicine.medical_specialty
Insomnia
National Health Programs
lcsh:RC435-571
Epidemiology
Primary Insomnia
Population
Taiwan
Comorbidity
Cohort Studies
03 medical and health sciences
Young Adult
0302 clinical medicine
Risk Factors
Internal medicine
lcsh:Psychiatry
Sleep Initiation and Maintenance Disorders
mental disorders
Medicine
Dementia
Humans
030212 general & internal medicine
Neurodegeneration
education
Depression (differential diagnoses)
Aged
Sleep disorder
education.field_of_study
business.industry
Middle Aged
medicine.disease
Psychiatry and Mental health
Case-Control Studies
Population Surveillance
Cohort
Female
business
030217 neurology & neurosurgery
Cohort study
Research Article
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 1471244X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- BMC Psychiatry
- Accession number :
- edsair.doi.dedup.....6d173538386134f49bf01b22d8b00cb2