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Genome-wide divergence among invasive populations of Aedes aegypti in California
- Source :
- BMC genomics, vol 20, iss 1, BMC Genomics, Vol 20, Iss 1, Pp 1-10 (2019), BMC Genomics, Lee, Yoosook; Schmidt, Hanno; Collier, Travis C; Conner, William R; Hanemaaijer, Mark J; Slatkin, Montgomery; et al.(2019). Genome-wide divergence among invasive populations of Aedes aegypti in California.. BMC genomics, 20(1), 204. doi: 10.1186/s12864-019-5586-4. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/0cp7p030
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- Background In the summer of 2013, Aedes aegypti Linnaeus was first detected in three cities in central California (Clovis, Madera and Menlo Park). It has now been detected in multiple locations in central and southern CA as far south as San Diego and Imperial Counties. A number of published reports suggest that CA populations have been established from multiple independent introductions. Results Here we report the first population genomics analyses of Ae. aegypti based on individual, field collected whole genome sequences. We analyzed 46 Ae. aegypti genomes to establish genetic relationships among populations from sites in California, Florida and South Africa. Based on 4.65 million high quality biallelic SNPs, we identified 3 major genetic clusters within California; one that includes all sample sites in the southern part of the state (South of Tehachapi mountain range) plus the town of Exeter in central California and two additional clusters in central California. Conclusions A lack of concordance between mitochondrial and nuclear genealogies suggests that the three founding populations were polymorphic for two main mitochondrial haplotypes prior to being introduced to California. One of these has been lost in the Clovis populations, possibly by a founder effect. Genome-wide comparisons indicate extensive differentiation between genetic clusters. Our observations support recent introductions of Ae. aegypti into California from multiple, genetically diverged source populations. Our data reveal signs of hybridization among diverged populations within CA. Genetic markers identified in this study will be of great value in pursuing classical population genetic studies which require larger sample sizes. Electronic supplementary material The online version of this article (10.1186/s12864-019-5586-4) contains supplementary material, which is available to authorized users.
- Subjects :
- 0106 biological sciences
Genome, Insect
01 natural sciences
Genome
Medical and Health Sciences
Invasive species
California
Divergence
Population genomics
0302 clinical medicine
Aedes aegypti
Genome Size
Aedes
Phylogeny
0303 health sciences
education.field_of_study
biology
Biological Sciences
Phylogeography
Biotechnology
Research Article
lcsh:QH426-470
Evolution
Bioinformatics
lcsh:Biotechnology
030231 tropical medicine
Population
Genomics
Single-nucleotide polymorphism
Mosquito Vectors
Evolution, Molecular
03 medical and health sciences
lcsh:TP248.13-248.65
Information and Computing Sciences
Genetics
Animals
education
030304 developmental biology
Whole Genome Sequencing
Human Genome
Molecular
Genetic Variation
biology.organism_classification
lcsh:Genetics
Genetics, Population
Evolutionary biology
Genetic marker
Metagenomics
Introduced Species
Insect
010606 plant biology & botany
Founder effect
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- BMC genomics, vol 20, iss 1, BMC Genomics, Vol 20, Iss 1, Pp 1-10 (2019), BMC Genomics, Lee, Yoosook; Schmidt, Hanno; Collier, Travis C; Conner, William R; Hanemaaijer, Mark J; Slatkin, Montgomery; et al.(2019). Genome-wide divergence among invasive populations of Aedes aegypti in California.. BMC genomics, 20(1), 204. doi: 10.1186/s12864-019-5586-4. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/0cp7p030
- Accession number :
- edsair.doi.dedup.....6d1c7b22622f040c38c833bfdf0532d8