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Cantharimide and Its Derivatives from the Blister Beetle Mylabris phalerata Palla
- Source :
- Journal of natural products. 79(8)
- Publication Year :
- 2016
-
Abstract
- Eleven new monoterpenoids including three 1-methyl cantharimide-type derivatives (1–3), five 1,2-dimethyl cantharimide-type derivatives (4, 5, 7–9), and three 1-hydroxymethyl-2-methyl cantharimide-type derivatives (10–12), together with seven known cantharimides (6, 13–18), were isolated from Mylabis phalerata Palla. The planar structures and absolute configurations of compounds 1–14 were fully elucidated on the basis of spectroscopic analysis, ECD spectra, single-crystal X-ray diffraction analysis, and chemical methods. Compounds 6, 15, 16, and 18 were found to be potent inhibitors of HBV virus, with IC50 values of 62, 42, 58, and 19 μM.
- Subjects :
- China
Stereochemistry
Blister beetle
Molecular Conformation
Pharmaceutical Science
010402 general chemistry
Crystallography, X-Ray
01 natural sciences
Molecular conformation
Analytical Chemistry
Inhibitory Concentration 50
Drug Discovery
Ic50 values
Inhibitory concentration 50
Organic chemistry
Animals
Nuclear Magnetic Resonance, Biomolecular
Pharmacology
biology
Molecular Structure
010405 organic chemistry
Chemistry
Organic Chemistry
biology.organism_classification
0104 chemical sciences
Coleoptera
Complementary and alternative medicine
Monoterpenes
Molecular Medicine
Mylabris phalerata
Subjects
Details
- ISSN :
- 15206025
- Volume :
- 79
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of natural products
- Accession number :
- edsair.doi.dedup.....6d37edd12bc05296dfbf8ad8a385912c