Effect of insulin and isoproterenol on lipid metabolism in porcine adipose tissue from different depots

Significant differences were found in the rates of lipogenesis, glucose oxidation and lipolysis in porcine adipose tissue from four depots; outer subcutaneous (OSC), middle subcutaneous (MSC), perirenal (PR) and omental (OM). Lipogenesis was stimulated by insulin in all depots in the order PR > OM > MSC > OSC. Lipolysis was stimulated by isoproterenol in all depots in the order PR > OM > MSC > OSC. Differences in lipid metabolism by the different depots may have an important impact on lipid accretion in vivo.