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Optimal Minimal Panels of Immunohistochemistry for Diagnosis of B-Cell Lymphoma for Application in Countries With Limited Resources and for Triaging Cases Before Referral to Specialist Centers
- Publication Year :
- 2016
-
Abstract
- Objectives: Establish and validate optimal minimal immunohistochemistry panels for usage in a staged algorithmic manner for precise diagnosis of B-cell lymphomas in countries with limited resources. Suggest short panels of immunostains to be used in referring units that refer suspected lymphomas to specialist diagnostic centers in resourceful countries. Methods: Significant proportion of six B-cell lymphomas has characteristic morphology requiring a short panel of confirmatory immunostains. The rest would go through five different algorithms. Results: 812 cases in which a B-cell lymphoma or an HIV-associated lymphoma was suspected on morphological grounds were evaluated. This led to arriving at a specific diagnosis of 799 B-cell lymphomas. A correct diagnosis was achievable in 69% cases with the application of three to five antibodies; others required additional work-up. Conclusions: The panels/algorithms assist pathologists in practicing lymphoma diagnostics in countries with limited resources and in making lymphoma referrals to specialist centers.
- Subjects :
- medicine.medical_specialty
Lymphoma, B-Cell
Referral
Lymphoma
03 medical and health sciences
Patient referral
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
Diagnosis
medicine
Biomarkers, Tumor
Humans
Intensive care medicine
B-cell lymphoma
Developing Countries
Characteristic morphology
Tumor
business.industry
Classification
Developing countries
Immunohistochemistry
Algorithms
B-Cell
General Medicine
medicine.disease
Surgery
030220 oncology & carcinogenesis
business
Limited resources
Biomarkers
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6d552ef3b67cce83cee890ac1f762a24