Back to Search
Start Over
Nephrin and Podocalyxin - New Podocyte Proteins for Early Detection of Secondary Nephropathies
- Source :
- BANTAO Journal, Vol 14, Iss 1, Pp 11-16 (2016)
- Publication Year :
- 2016
- Publisher :
- Walter de Gruyter GmbH, 2016.
-
Abstract
- In the last two decades a great progress was observed in understanding of podocytes, their specific structure and function identifying many specific podocyte proteins, such as nephrin and podocalyxin. Podocytes form the final barrier to plasma proteins leakage. Nephrin as a main component of the filtration diaphragm forms a physical barrier while podocalyxin as sialoglycoprotein forms an electrostatic barrier. Podocyte damage, i.e. podocytopathies and their loss through urine-podocyturia, are crucial in pathogenesis and progression of nephropathies with proteinuria as main clinical manifestation. In podocytopathies, nephrin and podocalyxin appear in the urine before proteinuria and microalbuminuria which were previously considered as earliest markers of nephropathies. Nephrinuria and podocalyxuria indicate damage of the podocytes on glomerular level and/or presence of apoptotic and necrotic podocytes in urine. These urinary markers are also important in early diagnosis of secondary nephropathies such as diabetic, lupus and hypertensive nephropathy as the most common causes of end-stage renal failure (ESRF). These markers are also important in the prediction of preeclampsia, which is the most common complication in pregnancy. In this review we elaborate in dept the main structural and functional features of podocytes and their specific proteins, nephrin and podocalyxin, summarizing the recent literature data on their importance in the early diagnosis of the most common secondary nephropathies.
- Subjects :
- 0301 basic medicine
Nephrology
medicine.medical_specialty
Pathology
Early detection
030204 cardiovascular system & hematology
urologic and male genital diseases
Podocyte
Nephrin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
podocytopathies
Transplantation
biology
business.industry
nephrin
podocalyxin
RC31-1245
female genital diseases and pregnancy complications
podocytes
030104 developmental biology
medicine.anatomical_structure
Podocalyxin
chemistry
biology.protein
secondary nephropathies
business
Subjects
Details
- ISSN :
- 24513105
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- BANTAO Journal
- Accession number :
- edsair.doi.dedup.....6d666cb58436b27b6d4cd2f54c2a7a2d