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Concomitant diagnosis of endometrial and breast cancer - does the sequence matters?

Concomitant diagnosis of endometrial and breast cancer - does the sequence matters?

Authors :
Shira Peleg Hasson
Tamar Safra
Ido Wolf
Keren Levanon
Akram Saad
Nadav Michaan
Ido Laskov
Tomer Stern
Source :
Gynecologic Oncology Reports, Vol 38, Iss, Pp 100863-(2021), Gynecologic Oncology Reports
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Highlights • Patients suffering from both breast and endometrial cancer seem to have unique characteristics. • The sequence of occurrence of malignancies appears to have significance. • In patients that endometrial cancer was diagnosed as a second tumor, it tended to present in a more aggressive form. • In this group, a longer time interval between diagnoses might offer diagnostic and prophylactic opportunities. • No correlation was found to tamoxifen usage among patients.<br />Objective To examine whether patients with both breast cancer (BC) and endometrial cancer (EC) have different features of disease, and whether the sequence of appearance of these tumors is correlated with a more aggressive course. Methods A retrospective, multi-center observational cohort study of patients treated in two tertiary medical centers between 2014 and 2020. Files of patients who had a co-diagnosis of BC and EC were reviewed and clinical, epidemiological, pathological and genetic characteristics were collected. Results 67 patients with a co-diagnosis of both malignances were divided into two groups according to primary tumor diagnosis: BC first group (43/67, 64%) and EC first group (24/67, 36%). The time interval between diagnosis of malignancies was significantly longer in the BC first group (mean 144.5 months vs. 67 months, p

Details

Language :
English
ISSN :
23525789
Volume :
38
Database :
OpenAIRE
Journal :
Gynecologic Oncology Reports
Accession number :
edsair.doi.dedup.....6d7020594d089dadd8d1ebbebee00be6