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Concomitant diagnosis of endometrial and breast cancer - does the sequence matters?
Concomitant diagnosis of endometrial and breast cancer - does the sequence matters?
- Source :
- Gynecologic Oncology Reports, Vol 38, Iss, Pp 100863-(2021), Gynecologic Oncology Reports
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Highlights • Patients suffering from both breast and endometrial cancer seem to have unique characteristics. • The sequence of occurrence of malignancies appears to have significance. • In patients that endometrial cancer was diagnosed as a second tumor, it tended to present in a more aggressive form. • In this group, a longer time interval between diagnoses might offer diagnostic and prophylactic opportunities. • No correlation was found to tamoxifen usage among patients.<br />Objective To examine whether patients with both breast cancer (BC) and endometrial cancer (EC) have different features of disease, and whether the sequence of appearance of these tumors is correlated with a more aggressive course. Methods A retrospective, multi-center observational cohort study of patients treated in two tertiary medical centers between 2014 and 2020. Files of patients who had a co-diagnosis of BC and EC were reviewed and clinical, epidemiological, pathological and genetic characteristics were collected. Results 67 patients with a co-diagnosis of both malignances were divided into two groups according to primary tumor diagnosis: BC first group (43/67, 64%) and EC first group (24/67, 36%). The time interval between diagnosis of malignancies was significantly longer in the BC first group (mean 144.5 months vs. 67 months, p
- Subjects :
- Research Report
Oncology
medicine.medical_specialty
BRCA
Endometrial Cancer
Uterine serous carcinoma
Breast cancer
Internal medicine
Epidemiology
Breast Cancer
medicine
RC254-282
business.industry
Endometrial cancer
Obstetrics and Gynecology
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Gynecology and obstetrics
medicine.disease
Primary tumor
Tamoxifen
Concomitant
RG1-991
business
medicine.drug
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 23525789
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology Reports
- Accession number :
- edsair.doi.dedup.....6d7020594d089dadd8d1ebbebee00be6