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Artificial neural network classification based on capillary electrophoresis of urinary nucleosides for the clinical diagnosis of tumors
- Source :
- Journal of Chromatography A. 828:489-496
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- Nucleosides in human urine have been studied frequently as a possible biomedical marker for cancers, acquired immune deficiency syndrome (AIDS) and the whole-body turnover of RNAs. A capillary electrophoretic method that can quantitatively analyze urinary normal and modified nucleosides in less than 40 min with a good resolution and sufficient sensitivity has been developed. Twelve kinds of normal and modified nucleosides were determined in urine samples from 25 healthy persons and 25 cancer patients of 14 kinds of cancers. Artificial neural networks have been used as a powerful pattern recognition tool to distinguish cancer patients from healthy persons. The recognition rate for the training set reached to 100% and above 85% of the members in the predicting set were correctly classified. In addition, the neural network technique was compared with methods of the principal component analysis and the canonical discriminant analysis. The results demonstrate that the predictive ability of the artificial neural network is stronger than the others in this study.
- Subjects :
- Chromatography
Artificial neural network
Chemistry
Urinary system
Organic Chemistry
Discriminant Analysis
Electrophoresis, Capillary
Cancer
Nucleosides
General Medicine
Urine
Computational biology
medicine.disease
Linear discriminant analysis
Biochemistry
Analytical Chemistry
Capillary electrophoresis
Neoplasms
Principal component analysis
Biomarkers, Tumor
medicine
Humans
Neural Networks, Computer
Canonical discriminant analysis
Subjects
Details
- ISSN :
- 00219673
- Volume :
- 828
- Database :
- OpenAIRE
- Journal :
- Journal of Chromatography A
- Accession number :
- edsair.doi.dedup.....6d7d9c660acb142cbf3642044734a490