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Fracture is additionally attributed to hyperhomocysteinemia in men and premenopausal women with type 2 diabetes
- Source :
- Journal of Diabetes Investigation
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Aims/Introduction Data on hyperhomocysteinemia in relation to fractures in diabetes are limited. We aimed to explore the relationship between plasma total homocysteine concentrations and fractures in men and premenopausal women with type 2 diabetes. Materials and Methods Diabetic and control participants (n = 292) were enrolled in a cross-sectional hospital-based study. Bone mineral density and fractures were documented by dual energy X-ray absorptiometry and X-ray film, respectively. Plasma total homocysteine concentrations were measured using fluorescence polarization immunoassay. Risk factors for low bone mineral density or fractures and determinants of homocysteine were obtained from blood samples and the interviewer questionnaire. Results Plasma total homocysteine levels were higher in diabetic participants with fractures than without (8.6 [2.1] μmol/L vs 10.3 [3.0] μmol/L, P = 0.000). Diabetic participants with fractures had similar bone mineral densities as control participants. The association of homocysteine with the fracture was independent of possible risk factors for fractures (e.g., age, duration of diabetes, glycated hemoglobin, body mass index, thiazolidenediones and retinopathy) and determinants of homocysteine concentration (e.g., age, sex, serum folate and vitamin B12, renal status and biguanide use; odds ratio 1.41, 95% confidence interval 1.05–2.03, P = 0.020). Furthermore, per increase of 5.0 μmol/L plasma homocysteine was related to the fracture, after controlling for per unit increase of other factors (odds ratio 1.42, 95% confidence interval 1.12–1.78, P = 0.013). Conclusions Plasma total homocysteine concentration is independently associated with occurrence of fractures in men and premenopausal women with type 2 diabetes. Future prospective studies are warranted to clarify the relationship.
- Subjects :
- medicine.medical_specialty
Hyperhomocysteinemia
Homocysteine
Endocrinology, Diabetes and Metabolism
Men and premenopausal women with type 2 diabetes
Type 2 diabetes
Gastroenterology
chemistry.chemical_compound
Diabetes mellitus
Internal medicine
Internal Medicine
Medicine
Bone mineral
business.industry
Articles
General Medicine
Odds ratio
medicine.disease
Clinical Science and Care
Fracture
Endocrinology
chemistry
Original Article
Glycated hemoglobin
business
Body mass index
Subjects
Details
- ISSN :
- 20401116
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Investigation
- Accession number :
- edsair.doi.dedup.....6d89ca193ca3fb0bf0fc71dcb50fca8e