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Combined approaches to identify genomic regions involved in phenotypic differentiation between low divergent breeds: Application in Sardinian sheep populations
- Source :
- Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und ZuchtungsbiologieREFERENCES. 136(6)
- Publication Year :
- 2019
-
Abstract
- Selective breeding has led to modifications in the genome of many livestock breeds. In this study, we identified the genomic regions that may explain some of the phenotypic differences between two closely related breeds from Sardinia. A total of 44 animals, 20 Sardinian Ancestral Black (SAB) and 24 Sardinian White (SW), were genotyped using the Illumina Ovine 50K array. A total of 68, 38 and 15 significant markers were identified using the case–control genome-wide association study (GWAS), the Bayesian population differentiation analysis (FST) and the Rsb metric, respectively. Comparisons among the approaches revealed a total of 22 overlapping markers between GWAS and FST and one marker between GWAS and Rsb. Three markers detected by Rsb were also located near (
- Subjects :
- Coat
Genotype
Population
Genome-wide association study
genome-wide methods
Biology
Selective breeding
Genome
Polymorphism, Single Nucleotide
Settore AGR/17 - Zootecnica Generale E Miglioramento Genetico
Food Animals
genomic regions
Ovine BeadChip50K
Sardinian sheep breeds
Animals
Genetic variability
education
Gene
education.field_of_study
Sheep
Homozygote
Molecular Sequence Annotation
General Medicine
Genomics
genome-wide method
genomic region
White (mutation)
Phenotype
Evolutionary biology
Animal Science and Zoology
Subjects
Details
- ISSN :
- 14390388
- Volume :
- 136
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und ZuchtungsbiologieREFERENCES
- Accession number :
- edsair.doi.dedup.....6d8d7ef0392a11d45aa87ed49520c1cc