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Acute and Subacute Oral Toxicity Evaluation of Eriobotrya japonica Leaf Triterpene Acids in ICR Mice
- Source :
- Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017)
- Publication Year :
- 2017
- Publisher :
- Hindawi Limited, 2017.
-
Abstract
- The interest focusing on Eriobotrya japonica leaf triterpene acid (ELTA) has increased recently because of its beneficial effects on health. However, there has been a lack of experimental data on its toxicity. The present study therefore was conducted to evaluate its toxicity in ICR mice. The results showed that ELTA produced neither mortality nor toxicity of the main organs in ICR male and female mice in both acute (0.30, 0.65, 1.39, and 3.00 g·kg−1 body weight) and subacute (150, 300, and 600 mg·kg−1 BW) 28-day toxicity studies. Because of lacking apparently adverse effects found in the hematology, clinical biochemistry, and histopathology evaluation, results of the present study together with the beneficial effects make ELTA as a promising dietary supplement and indicated that ELTA administered orally might have a large safety margin for human.
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
medicine.medical_specialty
Hematology
Article Subject
lcsh:Other systems of medicine
Biology
Pharmacology
lcsh:RZ201-999
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Complementary and alternative medicine
Triterpene
chemistry
030220 oncology & carcinogenesis
Internal medicine
Toxicity
medicine
Histopathology
Oral toxicity
ERIOBOTRYA JAPONICA LEAF
Adverse effect
Icr mice
Research Article
Subjects
Details
- ISSN :
- 17414288 and 1741427X
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- Evidence-Based Complementary and Alternative Medicine
- Accession number :
- edsair.doi.dedup.....6d8ee36257967d9dd34312cdf039bade