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Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder
- Source :
- BMC Medical Genetics, BMC Medical Genetics, BioMed Central, 2010, 11, pp.100. ⟨10.1186/1471-2350-11-100⟩, BMC Medical Genetics, Vol 11, Iss 1, p 100 (2010), BMC Medical Genetics, 2010, 11, pp.100. ⟨10.1186/1471-2350-11-100⟩
- Publication Year :
- 2010
- Publisher :
- HAL CCSD, 2010.
-
Abstract
- Background Obsessive-compulsive disorder (OCD) is a clinically and etiologically heterogeneous syndrome. The high frequency of obsessive-compulsive symptoms reported in subjects with the 22q11.2 deletion syndrome (DiGeorge/velocardiofacial syndrome) or Prader-Willi syndrome (15q11-13 deletion of the paternally derived chromosome), suggests that gene dosage effects in these chromosomal regions could increase risk for OCD. Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients. Methods We screened the 15q11-13 and 22q11.2 chromosomal regions for genomic imbalances in 236 patients with OCD using multiplex ligation-dependent probe amplification (MLPA). Results No deletions or duplications involving 15q11-13 or 22q11.2 were identified in our patients. Conclusions Our results suggest that deletions/duplications of chromosomes 15q11-13 and 22q11.2 are rare in OCD. Despite the negative findings in these two regions, the search for copy number variants in OCD using genome-wide array-based methods is a highly promising approach to identify genes of etiologic importance in the development of OCD.
- Subjects :
- Male
Obsessive-Compulsive Disorder
Chromosomes, Human, Pair 22
Gene Dosage
[SDV.GEN] Life Sciences [q-bio]/Genetics
MESH: Gene Dosage
0302 clinical medicine
Segmental Duplications, Genomic
DiGeorge syndrome
MESH: Child
Genetics(clinical)
MESH: Syndrome
Copy-number variation
MESH: Chromosomes, Human, Pair 22
Child
Genetics (clinical)
Sequence Deletion
Genetics
0303 health sciences
MESH: Middle Aged
MESH: Genetic Predisposition to Disease
Syndrome
Middle Aged
MESH: Sequence Deletion
3. Good health
MESH: Young Adult
Female
MESH: DNA Copy Number Variations
Chromosome Deletion
Prader-Willi Syndrome
Research Article
Adult
medicine.medical_specialty
lcsh:Internal medicine
lcsh:QH426-470
Adolescent
DNA Copy Number Variations
MESH: Chromosome Deletion
Biology
Gene dosage
behavioral disciplines and activities
03 medical and health sciences
Young Adult
MESH: Segmental Duplications, Genomic
mental disorders
medicine
DiGeorge Syndrome
Humans
Genetic Predisposition to Disease
Multiplex ligation-dependent probe amplification
lcsh:RC31-1245
Gene
030304 developmental biology
MESH: Adolescent
MESH: Obsessive-Compulsive Disorder
Chromosomes, Human, Pair 15
[SDV.GEN]Life Sciences [q-bio]/Genetics
MESH: Humans
MESH: DiGeorge Syndrome
Cytogenetics
Chromosome
MESH: Adult
medicine.disease
Human genetics
MESH: Male
lcsh:Genetics
MESH: Prader-Willi Syndrome
MESH: Female
030217 neurology & neurosurgery
MESH: Chromosomes, Human, Pair 15
Subjects
Details
- Language :
- English
- ISSN :
- 14712350
- Database :
- OpenAIRE
- Journal :
- BMC Medical Genetics, BMC Medical Genetics, BioMed Central, 2010, 11, pp.100. ⟨10.1186/1471-2350-11-100⟩, BMC Medical Genetics, Vol 11, Iss 1, p 100 (2010), BMC Medical Genetics, 2010, 11, pp.100. ⟨10.1186/1471-2350-11-100⟩
- Accession number :
- edsair.doi.dedup.....6d92d7255cbbd60144c718e7f0a96027