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Molecular characterization of colorectal cancer related peritoneal metastatic disease
- Source :
- Nature Communications, 13(1). Nature Publishing Group, Nature Communications, 13(1):4443. Nature Publishing Group, Nature Communications, 13(1):4443. Nature Publishing Group UK, Nature communications, 13(1):4443. Nature Publishing Group, Lenos, K J, Bach, S, Ferreira Moreno, L, ten Hoorn, S, Sluiter, N R, Bootsma, S, Vieira Braga, F A, Nijman, L E, van den Bosch, T, Miedema, D M, van Dijk, E, Ylstra, B, Kulicke, R, Davis, F P, Stransky, N, Smolen, G A, Coebergh van den Braak, R R J, IJzermans, J N M, Martens, J W M, Hallam, S, Beggs, A D, Kops, G J P L, Lansu, N, Bastiaenen, V P, Klaver, C E L, Lecca, M C, el Makrini, K, Elbers, C C, Dings, M P G, van Noesel, C J M, Kranenburg, O, Medema, J P, Koster, J, Koens, L, Punt, C J A, Tanis, P J, de Hingh, I H, Bijlsma, M F, Tuynman, J B & Vermeulen, L 2022, ' Molecular characterization of colorectal cancer related peritoneal metastatic disease ', Nature Communications, vol. 13, no. 1, 4443 . https://doi.org/10.1038/s41467-022-32198-z
- Publication Year :
- 2022
-
Abstract
- A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity.
- Subjects :
- Peritoneal Neoplasms/genetics
PROGNOSIS
INSTABILITY
CARCINOMATOSIS
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
Peritoneum/metabolism
SDG 3 - Good Health and Well-being
BRAF MUTATION
Neoplasms
COLON
KRAS
Humans
Peritoneal Neoplasms
Colorectal Neoplasms/pathology
Multidisciplinary
IDENTIFICATION
Neoplasms, Second Primary
General Chemistry
PREVALENCE
FAMILY
Second Primary
Quality of Life
Peritoneum
Colorectal Neoplasms
ERM PROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, 13(1). Nature Publishing Group, Nature Communications, 13(1):4443. Nature Publishing Group, Nature Communications, 13(1):4443. Nature Publishing Group UK, Nature communications, 13(1):4443. Nature Publishing Group, Lenos, K J, Bach, S, Ferreira Moreno, L, ten Hoorn, S, Sluiter, N R, Bootsma, S, Vieira Braga, F A, Nijman, L E, van den Bosch, T, Miedema, D M, van Dijk, E, Ylstra, B, Kulicke, R, Davis, F P, Stransky, N, Smolen, G A, Coebergh van den Braak, R R J, IJzermans, J N M, Martens, J W M, Hallam, S, Beggs, A D, Kops, G J P L, Lansu, N, Bastiaenen, V P, Klaver, C E L, Lecca, M C, el Makrini, K, Elbers, C C, Dings, M P G, van Noesel, C J M, Kranenburg, O, Medema, J P, Koster, J, Koens, L, Punt, C J A, Tanis, P J, de Hingh, I H, Bijlsma, M F, Tuynman, J B & Vermeulen, L 2022, ' Molecular characterization of colorectal cancer related peritoneal metastatic disease ', Nature Communications, vol. 13, no. 1, 4443 . https://doi.org/10.1038/s41467-022-32198-z
- Accession number :
- edsair.doi.dedup.....6dcfd81493869ac6931a7e0acacc5819
- Full Text :
- https://doi.org/10.1038/s41467-022-32198-z