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Dietary Total Antioxidant Capacity is Inversely Associated with Prostate Cancer Aggressiveness in a Population-Based Study
- Source :
- Nutrition and Cancer. 68:214-224
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- The purpose of this study was to determine the relationship between total antioxidant capacity (TAC) from diet and supplements and prostate cancer aggressiveness among 855 African Americans (AA) and 945 European Americans (EA) in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Cases were classified as either high aggressive, low aggressive, or intermediate aggressive. TAC was calculated from the vitamin C equivalent antioxidant capacity of 42 antioxidants measured via food frequency questionnaire. EA reported greater dietary TAC from diet and supplements combined (P0.0001). In both minimally and fully adjusted logistic regression models, TAC from diet and supplements combined was associated with a reduced odds of high aggressive prostate cancer in all men, AA and EA: odds ratios for highest vs. lowest level (1500 vs.500 mg vitamin C equivalent/day): 0.31 [95% confidence interval (CI): 0.15, 0.67; P-trend0.01], 0.28 (95% CI: 0.08, 0.96; P-trend0.001), and 0.36 (95% CI: 0.15, 0.86; P-trend = 0.58), respectively. These associations did not appear to differ between AA and EA. These data suggest that greater intake of antioxidants is associated with less aggressive prostate cancer. Additional research is needed to confirm these results and determine the underlying mechanisms.
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Prostate Cancer Aggressiveness
Medicine (miscellaneous)
Ascorbic Acid
Antioxidants
White People
Article
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Internal medicine
North Carolina
medicine
Humans
Aged
030109 nutrition & dietetics
Nutrition and Dietetics
Vitamin C
business.industry
Prostatic Neoplasms
Feeding Behavior
Middle Aged
Louisiana
medicine.disease
Ascorbic acid
Confidence interval
Additional research
Black or African American
Population based study
Antioxidant capacity
Logistic Models
Socioeconomic Factors
030220 oncology & carcinogenesis
Dietary Supplements
Immunology
business
Subjects
Details
- ISSN :
- 15327914 and 01635581
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Nutrition and Cancer
- Accession number :
- edsair.doi.dedup.....6dd2519fa4b1d671ce2f5e9fd0d1c1c8