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Post-transplant day +100 MRD detection rather than mixed chimerism predicts relapses after allo-SCT for intermediate risk AML patients transplanted in CR
- Source :
- Klyuchnikov, Evgeny; Badbaran, Anita; Massoud, Radwan; Fritsche-Friedland, Ulrike; Freiberger, Petra; Ayuk, Francis; Wolschke, Christine; Bacher, Ulrike; Kröger, Nicolaus (2022). Post-transplant day +100 MRD detection rather than mixed chimerism predicts relapses after allo-SCT for intermediate risk AML patients transplanted in CR. Transplantation and cellular therapy, 28(7), 374.e1-374.e9. Elsevier 10.1016/j.jtct.2022.04.009
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- BACKGROUND Chimerism and minimal residual disease (MRD) are suggested to be prognostic for post-transplant relapses in AML patients. Nevertheless, the predictive values of both approaches in homogeneous population remain underinvestigated. Here, we suggest that MRD may have a higher predictive value for relapses than mixed chimerism (MC) in intermediate risk AML patients. PATIENTS AND METHODS 79 patients with intermediate risk AML (male, n=40, median age, 57 (19-77)) were included. MRD detection on day +100 was performed in bone marrow (multiparameter flow cytometry and quantitative real-time PCR for NPM1-mutated patients). Chimerism analysis was measured in peripheral blood. MC was defined as persistence of
- Subjects :
- body regions
hemic and lymphatic diseases
610 Medicine & health
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Klyuchnikov, Evgeny; Badbaran, Anita; Massoud, Radwan; Fritsche-Friedland, Ulrike; Freiberger, Petra; Ayuk, Francis; Wolschke, Christine; Bacher, Ulrike; Kröger, Nicolaus (2022). Post-transplant day +100 MRD detection rather than mixed chimerism predicts relapses after allo-SCT for intermediate risk AML patients transplanted in CR. Transplantation and cellular therapy, 28(7), 374.e1-374.e9. Elsevier 10.1016/j.jtct.2022.04.009 <http://dx.doi.org/10.1016/j.jtct.2022.04.009>
- Accession number :
- edsair.doi.dedup.....6dd3142cec9d9ee8259b4b80003517e7
- Full Text :
- https://doi.org/10.48350/169364