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The rescue of developing avian motoneurons from programmed cell death by a selective inhibitor of the fetal muscle-specific nicotinic acetylcholine receptor
- Source :
- Developmental Neurobiology. 68:972-980
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- In an attempt to determine whether the rescue of developing motoneurons (MNS) from programmed cell death (PCD) in the chick embryo following reductions in neuromuscular function involves muscle or neuronal nicotinic acetylcholine receptors (nAChRs), we have employed a novel cone snail toxin αA-OIVA that acts selectively to antagonize the embryonic/fetal form of muscle nAChRs. The results demonstrate that αA-OIVA is nearly as effective as curare or α-bungarotoxin (α-BTX) in reducing neuromuscular function and is equally effective in increasing MN survival and intramuscular axon branching. Together with previous reports, we also provide evidence consistent with a transition between the embryonic/fetal form to the adult form of muscle nAChRs in chicken that involves the loss of the gamma subunit in the adult receptor. We conclude that selective inhibition of the embryonic/fetal form of the chicken muscle nAChR is sufficient to rescue MNs from PCD without any involvement of neuronal nAChRs. © 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008
- Subjects :
- Programmed cell death
animal structures
Cell Survival
Movement
Neuromuscular Junction
Apoptosis
Chick Embryo
Nicotinic Antagonists
Receptors, Nicotinic
Biology
Peptides, Cyclic
complex mixtures
Cellular and Molecular Neuroscience
Developmental Neuroscience
Tubulin
medicine
Animals
Receptor
Acetylcholine receptor
Motor Neurons
Fetus
Bungarotoxins
Embryonic stem cell
Axons
Curare
Nicotinic acetylcholine receptor
Nicotinic agonist
nervous system
embryonic structures
Conotoxins
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 1932846X and 19328451
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Developmental Neurobiology
- Accession number :
- edsair.doi.dedup.....6dd604c71d66af1246e0899d3f1436b0