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Penetrance and clinical features of pheochromocytoma in a six-generation family carrying a germline TMEM127 mutation
Penetrance and clinical features of pheochromocytoma in a six-generation family carrying a germline TMEM127 mutation
- Source :
- The Journal of clinical endocrinology and metabolism. 100(2)
- Publication Year :
- 2014
-
Abstract
- Context: The phenotype of familial pheochromocytoma (PHEO) associated with germline TMEM127 mutations (TMEM127-related PHEO) has not been clearly defined. Objective: This study aimed to investigate the penetrance, full phenotypic spectrum and effectiveness of clinical/genetic screening in TMEM127-related PHEO. Design, Setting, and Participants: Clinical and genetic screening, and genetic counseling were offered to 151 individuals from a six-generation family carrying a TMEM127 germline mutation in a referral center. Intervention and Main Outcome Measures: TMEM127 genetic testing was offered to at-risk relatives and clinical surveillance for pheochromocytoma was performed in mutation-positive carriers. Results: Forty seven individuals carried the c.410-2A>C TMEM127 mutation. Clinical data were obtained from 34 TMEM127-mutation carriers followed up for 8.7 ± 8.1 years (range, 1–20 y). Pheochromocytoma was diagnosed in 11 carriers (32%) at a median age of 43 years. In nine patients, symptoms started at 29 years (range, 10–55 y) and two cases were asymptomatic. Tumors were multicentric in five (45%) and bilateral in five (45%) patients. Six patients (54%) had at least one adrenomedullary nodule less than 10 mm. No paragangliomas, distant metastases, or other manifestations were detected. Cumulative penetrance of pheochromocytoma was 0% at 0–20 years, 3% at 21–30 years, 15% at 31–40 years, 24% at 41–50 years, and 32% at 51–65 years. The youngest case was diagnosed at 22 years and the earliest symptoms were reported at age 10. Conclusions: Tumor multicentricity, nodular adrenomedullary hyperplasia, and the occurrence of symptoms more than a decade earlier than the age at diagnosis are novel findings in TMEM127-related PHEO. The high penetrance of pheochromocytoma in this condition validates the benefits of genetic testing of at-risk relatives. We thus recommend that TMEM127 genetic testing should be offered to at-risk individuals at age 22 years and mutation carriers should undergo clinical surveillance annually.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Genetic counseling
Clinical Biochemistry
Adrenal Gland Neoplasms
Context (language use)
Penetrance
Pheochromocytoma
Biochemistry
Young Adult
Endocrinology
Germline mutation
Internal medicine
medicine
Humans
Family
Genetic Predisposition to Disease
Age of Onset
Germ-Line Mutation
Genetic testing
Genetics
medicine.diagnostic_test
business.industry
Biochemistry (medical)
Membrane Proteins
Middle Aged
medicine.disease
Pedigree
Phenotype
Mutation (genetic algorithm)
Female
Age of onset
business
Subjects
Details
- ISSN :
- 19457197
- Volume :
- 100
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....6ddddda061c0a80308a79b627fdd207f