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Surgical attenuation of spontaneous congenital portosystemic shunts in dogs resolves hepatic encephalopathy but not hypermanganesemia
- Source :
- Gow, A G, Frowde, P E, Elwood, C M, Burton, C A, Powell, R M, Tappin, S W, Foale, R D, Duncan, A & Mellanby, R J 2015, ' Surgical attenuation of spontaneous congenital portosystemic shunts in dogs resolves hepatic encephalopathy but not hypermanganesemia ', Metabolic brain disease, vol. 30, no. 5, pp. 1285-1289 . https://doi.org/10.1007/s11011-015-9676-y
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Hypermanganesemia is commonly recognized in human patients with hepatic insufficiency and portosystemic shunting. Since manganese is neurotoxic, increases in brain manganese concentrations have been implicated in the development of hepatic encephalopathy although a direct causative role has yet to be demonstrated. Evaluate manganese concentrations in dogs with a naturally occurring congenital shunt before and after attenuation as well as longitudinally following the changes in hepatic encephalopathy grade. Our study demonstrated that attenuation of the shunt resolved encephalopathy, significantly reduced postprandial bile acids, yet a hypermanganasemic state persisted. This study demonstrates that resolution of hepatic encephalopathy can occur without the correction of hypermanganesemia, indicating that increased manganese concentrations alone do not play a causative role in encephalopathy. Our study further demonstrates the value of the canine congenital portosystemic shunt as a naturally occurring spontaneous model of human hepatic encephalopathy.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Neurology
business.industry
Encephalopathy
Portosystemic shunting
medicine.disease
Biochemistry
Cellular and Molecular Neuroscience
Dogs
Postprandial
Hepatic Encephalopathy
medicine
Animals
Portasystemic Shunt, Surgical
Female
Magnesium
Neurology (clinical)
Portosystemic shunt
business
Hepatic encephalopathy
Shunt (electrical)
Subjects
Details
- ISSN :
- 15737365 and 08857490
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Metabolic Brain Disease
- Accession number :
- edsair.doi.dedup.....6de7993b33eedbcbcda87f574e9c13f1
- Full Text :
- https://doi.org/10.1007/s11011-015-9676-y