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A combined analysis of maximum standardized uptake value on FDG-PET, genetic markers, and clinicopathological risk factors in the prognostic stratification of patients with resected oral cavity squamous cell carcinoma
- Source :
- European journal of nuclear medicine and molecular imaging. 47(1)
- Publication Year :
- 2019
-
Abstract
- Clinical outcomes of patients with resected oral cavity squamous cell carcinoma (OCSCC) chiefly depend on the presence of specific clinicopathological risk factors (RFs). Here, we performed a combined analysis of FDG-PET, genetic markers, and clinicopathological RFs in an effort to improve prognostic stratification. We retrospectively reviewed the clinical records of 2036 consecutive patients with first primary OCSCC who underwent surgery between 1996 and 2016. Of them, 345 underwent ultra-deep targeted sequencing (UDTS, between 1996 and 2011) and 168 whole exome sequencing (WES, between 2007 and 2016). Preoperative FDG-PET imaging was performed in 1135 patients from 2001 to 2016. Complete data on FDG-PET, genetic markers, and clinicopathological RFs were available for 327 patients. Using log-ranked tests based on 5-year disease-free survival (DFS), the optimal cutoff points for maximum standardized uptake values (SUV-max) of the primary tumor and neck metastatic nodes were 22.8 and 9.7, respectively. The 5-year DFS rates were as follows: SUVtumor-max ≥ 22.8 or SUVnodal-max ≥ 9.7 (n = 77) versus SUVtumor-max
- Subjects :
- Genetic Markers
medicine.medical_specialty
Multivariate analysis
Standardized uptake value
Gastroenterology
Prognostic stratification
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Risk Factors
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Oral Cavity Squamous Cell Carcinoma
Pathological
Exome sequencing
Retrospective Studies
business.industry
Squamous Cell Carcinoma of Head and Neck
General Medicine
medicine.disease
Prognosis
Primary tumor
Genetic marker
030220 oncology & carcinogenesis
Positron-Emission Tomography
Lymph Nodes
Radiopharmaceuticals
business
Subjects
Details
- ISSN :
- 16197089
- Volume :
- 47
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European journal of nuclear medicine and molecular imaging
- Accession number :
- edsair.doi.dedup.....6de976e301da7fabd34ba8ce29f7f88e