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Ligand-Switchable Micellar Nanocarriers for Prolonging Circulation Time and Enhancing Targeting Efficiency
- Source :
- ACS applied materialsinterfaces. 10(6)
- Publication Year :
- 2018
-
Abstract
- Targeted drug delivery of nanomedicines offered a promising strategy to improve the tumor accumulation and reduce the side effects of chemotherapeutics. However, undesired recognition of the targeting ligands on the surface of nanocarriers by immune systems or normal tissues decreased the circulation time and reduced the targeting efficiency. Here, we developed a ligand-switchable micellar nanocarrier that can hide the targeting ligands when circulating in the bloodstream and expose them on the surface when entering the tumor microenvironments. With the ligand-switching capability, the nanocarrier achieved a 66% longer blood circulation half-life and a 23% higher tumor accumulation than the nanocarrier with targeting ligands on the surface. This targeting strategy could serve as a universal approach to improve the targeting efficiency for nanomedicines.
- Subjects :
- Tumor microenvironment
Drug Carriers
Materials science
Normal tissue
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Ligand (biochemistry)
Ligands
01 natural sciences
0104 chemical sciences
Nanostructures
Drug Delivery Systems
Nanomedicine
Targeted drug delivery
Blood circulation
Biophysics
Nanoparticles
General Materials Science
Circulation time
Nanocarriers
0210 nano-technology
Micelles
Targeting ligands
Subjects
Details
- ISSN :
- 19448252
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- ACS applied materialsinterfaces
- Accession number :
- edsair.doi.dedup.....6dec9a638ed9dbfcb21cebccb5b2fd7f