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Risk factors and clinical outcomes of Epstein-Barr virus DNAemia and post-transplant lymphoproliferative disorders after haploidentical and matched-sibling PBSCT in patients with hematologic malignancies
- Source :
- Annals of hematology. 98(9)
- Publication Year :
- 2019
-
Abstract
- In allogeneic hematopoietic stem cell transplantation recipients, reactivation of Epstein–Barr virus (EBV) can cause post-transplantation lymphoproliferative disorder (PTLD), which may rapidly progress to multiorgan failure and even death. Development of EBV PTLD correlates very closely with use of anti-thymocyte globulin (ATG) and type of transplant. To assess the incidences and clinical features of EBV DNAemia and PTLD in the setting of stem cell transplantation using unmanipulated G-CSF-primed allogeneic peripheral blood stem cells as graft, we performed a retrospective analysis of stem cell transplantation from HLA-matched sibling donors (MSD-SCT, n = 90) or HLA-haploidentical related donors (HID-SCT, n = 110) in patients with hematological malignancies. All of HID-SCT recipients and 27.8% of MSD-SCT recipients received an ATG-containing conditioning regimen. One-year cumulative incidence of EBV DNAemia was 44.1%, ranging from 4.8% in MSD-SCT recipients not using ATG to 20.0% in MSD-SCT recipients using ATG, and 73.7% in HID-SCT recipients. Risk factors for EBV reactivation included use of ATG (p = 0.008), male donor (p = 0.034), and cytomegalovirus DNAemia (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Transplantation Conditioning
Adolescent
medicine.medical_treatment
Lymphoproliferative disorders
Hematopoietic stem cell transplantation
Lower risk
medicine.disease_cause
Gastroenterology
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Risk Factors
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Cumulative incidence
Child
Retrospective Studies
Peripheral Blood Stem Cell Transplantation
Hematology
business.industry
Incidence (epidemiology)
Siblings
General Medicine
Middle Aged
medicine.disease
Allografts
Epstein–Barr virus
Lymphoproliferative Disorders
Transplantation
Survival Rate
surgical procedures, operative
030220 oncology & carcinogenesis
Hematologic Neoplasms
DNA, Viral
Female
business
030215 immunology
Subjects
Details
- ISSN :
- 14320584
- Volume :
- 98
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Annals of hematology
- Accession number :
- edsair.doi.dedup.....6e17dd1a45a620de0ec0be68746470a8