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Effects of cytokine and cytokine receptor gene variation on high anti-HB titers: Following up on Taiwan's neonatal hepatitis B immunization program
- Source :
- Clinica Chimica Acta. 413:1194-1198
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Background A significant percentage of Taiwanese neonatal HB immunization recipients have subsequently exhibited low anti-HB titers at non-protective or undetectable levels. Several mechanisms have been proposed to explain this phenomenon, including low vaccination responsiveness, deficient lymphocyte function, inappropriate antigen processing and presentation, and abnormal cytokine secretion. Methods To determine genetic influences resulting in high anti-HB titers, we divided a study cohort of 183 individuals into an anti-HBs ≥ 1000 mIU/mL group and a 10–1000 mIU/mL anti-HBs titer group. Chi-square tests were used to compare genotype and allelic frequencies between the two groups. Results Data from univariate and multivariate regression analyses of cytokine and cytokine receptor gene variants indicate (a) increased potential of high anti-HB titers in the presence of the TT genotype of the IL - 4 rs2243250 SNP (OR = 3.19; p = 0.012) and the AA genotype of the IL - 4R rs1805010 SNP (OR = 2.25; p = 0.048), and (b) individuals carrying the TT genotype of the IL - 4 rs2243250 SNP had anti-HB titers at levels that were almost twice as high as those in individuals carrying the CC genotype (478.8 mIU/mL and 290.3 mIU/mL, respectively; p = 0.033). Conclusion Genetic determinants, especially IL - 4 and IL - 4R , may contribute to high anti-HB titers in immune responses to HB vaccinations.
- Subjects :
- Adolescent
Genotype
medicine.medical_treatment
Lymphocyte
Clinical Biochemistry
Taiwan
Polymorphism, Single Nucleotide
Biochemistry
Cytokine Receptor Gene
Cohort Studies
Young Adult
Asian People
Gene Frequency
medicine
Humans
Hepatitis B Vaccines
Hepatitis B Antibodies
Immunization Programs
business.industry
Biochemistry (medical)
Infant
General Medicine
Hepatitis B
medicine.disease
Receptors, Interleukin-4
Neonatal hepatitis
Titer
Cytokine
medicine.anatomical_structure
Multivariate Analysis
Immunology
Cytokines
Cytokine secretion
Interleukin-4
business
Subjects
Details
- ISSN :
- 00098981
- Volume :
- 413
- Database :
- OpenAIRE
- Journal :
- Clinica Chimica Acta
- Accession number :
- edsair.doi.dedup.....6e51086dc2627fc2401c414c5ebfc22d