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Common variants at VRK2 and TCF4 conferring risk of schizophrenia
- Source :
- Human Molecular Genetics Vol. 20 Issue 20: pp. 4076-4081, RODERIC. Repositorio Institucional de la Universitat de Valéncia, instname, Human Molecular Genetics, Human molecular genetics 20, 4076-4081 (2011). doi:10.1093/hmg/ddr325, Human Molecular Genetics, 20, 20, pp. 4076-81, Human Molecular Genetics, 20, 4076-81, Human Molecular Genetics, 20(20), 4076-4081. Oxford University Press, Human molecular genetics, 20(20), 4076-4081. Oxford University Press, Human Molecular Genetics; Vol 20, Steinberg, S, de Jong, S, Andreassen, O A, Werge, T, Børglum, A D, Mors, O, Mortensen, P B, Gustafsson, O, Costas, J, Pietiläinen, O P H, Demontis, D, Papiol, S, Huttenlocher, J, Mattheisen, M, Breuer, R, Vassos, E, Giegling, I, Fraser, G, Walker, N, Tuulio-Henriksson, A, Suvisaari, J, Lönnqvist, J, Paunio, T, Agartz, I, Melle, I, Djurovic, S, Strengman, E, Jürgens, G, Glenthøj, B, Terenius, L, Hougaard, D M, Orntoft, T, Wiuf, C, Didriksen, M, Hollegaard, M V, Nordentoft, M, van Winkel, R, Kenis, G, Abramova, L, Kaleda, V, Arrojo, M, Sanjuán, J, Arango, C, Sperling, S, Rossner, M, Ribolsi, M, Magni, V, Siracusano, A, Christiansen, C, Kiemeney, L A & Irish Schizophrenia Genomics Consortium 2011, ' Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia ', Human Molecular Genetics, vol. 20, no. 20, pp. 4076-81 . https://doi.org/10.1093/hmg/ddr325
- Publication Year :
- 2011
-
Abstract
- To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10(-9)] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10(-9)). European Union LSHM-CT-2006-037761 PIAP-GA-2008-218251 HEALTH-F2-2009-223423 National Genome Research Network of the German Federal Ministry of Education and Research (BMBF) 01GS08144 01GS08147 National Institute of Mental Health R01 MH078075 N01 MH900001 MH074027 Centre of Excellence for Complex Disease Genetics of the Academy of Finland 213506 129680 Biocentrum Helsinki Foundation Faculty of Medicine, University of Helsinki Stanley Medical Research Institute Danish Council for Strategic Research 2101-07-0059 H. Lundbeck A/S Research Council of Norway 163070/V50 South-East Norway Health Authority 2004-123 Medical Research Council Ministerio de Sanidad y Consumo, Spain PI081522 Xunta de Galicia 08CSA005208PR Swedish Research Council Wellcome Trust 083948/Z/07/Z Max Planck Society Eli Lilly and Company info:eu-repo/grantAgreement/EC/FP7/218251
- Subjects :
- schizophrenia
sequence variants
TCF4
Genome-wide association study
Transcription Factor 4
0302 clinical medicine
VRK2 protein, human
Polymorphism (computer science)
Genotype
genetics [Schizophrenia]
Neurogranin
Genetics (clinical)
Schizophrenia
Risk
Alleles
Polymorphism, Single Nucleotide
Transcription Factors
Humans
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Genetic Predisposition to Disease
Protein-Serine-Threonine Kinases
Genome-Wide Association Study
Genetics
0303 health sciences
Association Studies Articles
Single Nucleotide
General Medicine
genetics [Transcription Factors]
3. Good health
Protein Serine-Threonine Kinases
Biology
genetics [Protein-Serine-Threonine Kinases]
Molecular epidemiology [NCEBP 1]
03 medical and health sciences
ddc:570
Polymorphism
Allele
genetics [Basic Helix-Loop-Helix Leucine Zipper Transcription Factors]
Settore MED/25 - Psichiatria
Molecular Biology
Molecular epidemiology Aetiology, screening and detection [NCEBP 1]
030304 developmental biology
Intron
Odds ratio
Molecular biology
TCF4 protein, human
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 09646906
- Database :
- OpenAIRE
- Journal :
- Human Molecular Genetics Vol. 20 Issue 20: pp. 4076-4081, RODERIC. Repositorio Institucional de la Universitat de Valéncia, instname, Human Molecular Genetics, Human molecular genetics 20, 4076-4081 (2011). doi:10.1093/hmg/ddr325, Human Molecular Genetics, 20, 20, pp. 4076-81, Human Molecular Genetics, 20, 4076-81, Human Molecular Genetics, 20(20), 4076-4081. Oxford University Press, Human molecular genetics, 20(20), 4076-4081. Oxford University Press, Human Molecular Genetics; Vol 20, Steinberg, S, de Jong, S, Andreassen, O A, Werge, T, Børglum, A D, Mors, O, Mortensen, P B, Gustafsson, O, Costas, J, Pietiläinen, O P H, Demontis, D, Papiol, S, Huttenlocher, J, Mattheisen, M, Breuer, R, Vassos, E, Giegling, I, Fraser, G, Walker, N, Tuulio-Henriksson, A, Suvisaari, J, Lönnqvist, J, Paunio, T, Agartz, I, Melle, I, Djurovic, S, Strengman, E, Jürgens, G, Glenthøj, B, Terenius, L, Hougaard, D M, Orntoft, T, Wiuf, C, Didriksen, M, Hollegaard, M V, Nordentoft, M, van Winkel, R, Kenis, G, Abramova, L, Kaleda, V, Arrojo, M, Sanjuán, J, Arango, C, Sperling, S, Rossner, M, Ribolsi, M, Magni, V, Siracusano, A, Christiansen, C, Kiemeney, L A & Irish Schizophrenia Genomics Consortium 2011, ' Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia ', Human Molecular Genetics, vol. 20, no. 20, pp. 4076-81 . https://doi.org/10.1093/hmg/ddr325
- Accession number :
- edsair.doi.dedup.....6e6c75c570a1866902c4a034d4600beb