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Language lateralization in temporal lobe epilepsy: a comparison between fMRI and the Wada Test
- Source :
- Epilepsia. 47(8)
- Publication Year :
- 2006
-
Abstract
- Summary: Purpose: Recent studies have claimed that language functional magnetic resonance imaging (f MRI) can identify language lateralization in patients with temporal lobe epilepsy (TLE) and that f MRI-based findings are highly concordant with the conventional assessment procedure of speech dominance, the intracarotid amobarbital test (IAT). Methods: To establish the power of language f MRI to detect language lateralization during presurgical assessment, we compared the findings of a semantic decision paradigm with the results of a standard IAT in 68 patients with chronic intractable right and left temporal lobe epilepsy (rTLE, n = 28; lTLE, n = 40) who consecutively underwent a presurgical evaluation program. The patient group also included 14 (20.6%) subjects with atypical (bilateral or right hemisphere) speech. Four raters used a visual analysis procedure to determine the laterality of speech-related activation individually for each patient. Results: Overall congruence between f MRI-based laterality and the laterality quotient of the IAT was 89.3% in rTLE and 72.5% in lTLE patients. Concordance was best in rTLE patients with left speech. In lTLE patients, language f MRI identified atypical, right hemisphere speech dominance in every case, but missed left hemisphere speech dominance in 17.2%. Frontal activations had higher concordance with the IAT than did activations in temporoparietal or combined regions of interest (ROIs). Because of methodologic problems, recognition of bilateral speech was difficult. Conclusions: These data provide evidence that language f MRI as used in the present study has limited correlation with the IAT, especially in patients with lTLE and with mixed speech dominance. Further refinements regarding the paradigms and analysis procedures will be needed to improve the contribution of language f MRI for presurgical assessment. Key Words: Language f MRI—Temporal lobe epilepsy—Language lateralization—Intracarotid amobarbital test.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
Audiology
Sensitivity and Specificity
Lateralization of brain function
Functional Laterality
Developmental psychology
Temporal lobe
Predictive Value of Tests
Aphasia
medicine
Humans
Speech
Language
Cerebral Cortex
Brain Mapping
medicine.diagnostic_test
Magnetic resonance imaging
Middle Aged
Magnetic Resonance Imaging
Lobe
medicine.anatomical_structure
Neurology
Epilepsy, Temporal Lobe
Injections, Intra-Arterial
Laterality
Wada test
Amobarbital
Neurology (clinical)
medicine.symptom
Psychology
Functional magnetic resonance imaging
Carotid Artery, Internal
Subjects
Details
- ISSN :
- 00139580
- Volume :
- 47
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Epilepsia
- Accession number :
- edsair.doi.dedup.....6e75ae13fa75b3f917f1731960198faf