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Activities of Daily Living and Depressive Symptoms in Patients with Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer’s Disease
- Source :
- Journal of Alzheimer's Disease. 49:1043-1050
- Publication Year :
- 2016
- Publisher :
- IOS Press, 2016.
-
Abstract
- Background: Subjective cognitive decline (SCD) may be an early indicator for an increased risk of dementia. The exact definition of SCD remains unclear and has recently become a major research interest. Objectives: To determine impairments in activities of daily living (ADL) and depressive symptoms in elderly individuals with SCD, mild cognitive impairment (MCI), and Alzheimer’s disease (AD). Methods: We included 752 consecutive patients suffering from SCD, non-amnestic (naMCI) or amnestic MCI (aMCI), AD, and 343 healthy controls into this prospective cohort study. A neuropsychological test battery, B-ADL and BDI-II was performed. Results: SCD patients showed a decreased performance in ADL compared to controls. Performance in ADL declined concurrently with cognitive abilities along the controls−SCD−naMCI−aMCI−AD continuum. Individuals with cognitive complains, no matter if SCD, MCI, or AD patients, reported more often depressive symptoms compared to healthy controls without complaints. Within all five cognitive subgroups, patients with depressive symptoms reported more difficulties in ADL in comparison to patients without depressive symptoms. Adjusting for depressive symptoms, there was no significant group difference between the control versus the SCD group (OR 1.1, CI 0.6–1.7). Conclusions: SCD is a heterogeneous clinical condition. Specific features such as slightly impaired ADL and depressive symptoms are associated with SCD. Clinical markers may serve as an indicator for preclinical AD and in combination with biomarkers guide to an early diagnosis of a progressive neurodegenerative disease.
- Subjects :
- Male
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Activities of daily living
Disease
Neuropsychological Tests
Alzheimer Disease
hemic and lymphatic diseases
Internal medicine
Activities of Daily Living
Odds Ratio
medicine
Humans
Dementia
Cognitive Dysfunction
Prospective Studies
Cognitive decline
Prospective cohort study
Depression (differential diagnoses)
Aged
medicine.diagnostic_test
Depression
General Neuroscience
General Medicine
Neuropsychological test
Middle Aged
medicine.disease
Psychiatry and Mental health
Clinical Psychology
Physical therapy
Female
Perception
Geriatrics and Gerontology
Alzheimer's disease
Psychology
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....6e785be7b8d539f66731ef56c24634de
- Full Text :
- https://doi.org/10.3233/jad-150785