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Influence of Insulin Receptor Single Nucleotide Polymorphisms on Glycaemic Control and Formation of Anti-Insulin Antibodies in Diabetes Mellitus
- Source :
- Massarenti, L, Aniol-Nielsen, C, Enevold, C, Toft-Hansen, H & Nielsen, C H 2022, ' Influence of Insulin Receptor Single Nucleotide Polymorphisms on Glycaemic Control and Formation of Anti-Insulin Antibodies in Diabetes Mellitus ', International Journal of Molecular Sciences, vol. 23, no. 12, 6481 . https://doi.org/10.3390/ijms23126481, International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6481
- Publication Year :
- 2022
-
Abstract
- Single nucleotide polymorphisms (SNPs) in insulin and insulin receptor genes may influence the interaction between the two molecules, as may anti-insulin antibodies (IAs), commonly found in patients with type 1 diabetes mellitus (T1D) or type 2 diabetes mellitus (T2D) treated with exogenous insulin. We examined the impact of two SNPs in the human insulin gene (INS), rs3842752 and rs689, and two in the insulin receptor gene (INSR) rs2245649 and rs2229429, on disease susceptibility, glycaemic control, and IAs formation in 100 T1D patients and 101 T2D patients treated with insulin. 79 individuals without diabetes were typed as healthy controls. The minor alleles of rs3842752 and rs689 in INS protected against T1D (OR: 0.50, p = 0.01 and OR: 0.44; p = 0.002, respectively). The minor alleles of both rs2245649 and rs2229429 in INSR were risk factors for poor glycaemic control (HbA1c ≥ 80 mmol/mol) in T1D (OR: 5.35, p = 0.009 and OR: 3.10, p = 0.01, respectively). Surprisingly, the minor alleles of rs2245649 and rs2229429 in INSR associated strongly with the absence of IAs in T1D (OR = 0.28, p = 0.008 and OR = 0.30, p = 0.002, respectively). In conclusion, the minor alleles of the investigated INS SNPs protect against T1D, and the minor alleles of the investigated INSR SNPs are associated with poor glycaemic control and the absence of IAs in T1D.
- Subjects :
- MECHANISM
endocrine system
diabetes
glycaemic control
anti-insulin antibodies (IAs) single nucleotide polymorphisms (SNPs)
insulin receptor
endocrine system diseases
Glycemic Control
VARIANTS
SUSCEPTIBILITY
Polymorphism, Single Nucleotide
Catalysis
Inorganic Chemistry
Humans
Insulin
Genetic Predisposition to Disease
Physical and Theoretical Chemistry
Molecular Biology
Spectroscopy
TYPE-1
RISK
COMPLICATIONS
MUTATIONS
Organic Chemistry
nutritional and metabolic diseases
General Medicine
ASSOCIATION
GENE
Receptor, Insulin
Computer Science Applications
PREVALENCE
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Massarenti, L, Aniol-Nielsen, C, Enevold, C, Toft-Hansen, H & Nielsen, C H 2022, ' Influence of Insulin Receptor Single Nucleotide Polymorphisms on Glycaemic Control and Formation of Anti-Insulin Antibodies in Diabetes Mellitus ', International Journal of Molecular Sciences, vol. 23, no. 12, 6481 . https://doi.org/10.3390/ijms23126481, International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6481
- Accession number :
- edsair.doi.dedup.....6e86cb74ce46a722cc6ef2bfe8705d24
- Full Text :
- https://doi.org/10.3390/ijms23126481