Back to Search
Start Over
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
- Source :
- Nature Medicine, Nature Medicine, Nature Publishing Group, 2017, 23 (7), pp.850-858. ⟨10.1038/nm.4345⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of action is poorly defined. Recent evidence implicates the gut microbiota as a site of metformin action. In a double-blind study, we randomized individuals with treatment-naive T2D to placebo or metformin for 4 months and showed that metformin had strong effects on the gut microbiome. These results were verified in a subset of the placebo group that switched to metformin 6 months after the start of the trial. Transfer of fecal samples (obtained before and 4 months after treatment) from metformin-treated donors to germ-free mice showed that glucose tolerance was improved in mice that received metformin-altered microbiota. By directly investigating metformin–microbiota interactions in a gut simulator, we showed that metformin affected pathways with common biological functions in species from two different phyla, and many of the metformin-regulated genes in these species encoded metalloproteins or metal transporters. Our findings provide support for the notion that altered gut microbiota mediates some of metformin's antidiabetic effects.
- Subjects :
- 0301 basic medicine
Male
endocrine system diseases
microbiome
microbiote digestif
Type 2 diabetes
Pharmacology
Gut flora
Feces
Mice
Glucose tolerance test
medicine.diagnostic_test
Gastrointestinal Microbiome
digestive, oral, and skin physiology
General Medicine
Fecal Microbiota Transplantation
Middle Aged
Metformin
3. Good health
Female
medicine.drug
DNA, Bacterial
diabète de type 2
Biology
In Vitro Techniques
Placebo
digestive system
General Biochemistry, Genetics and Molecular Biology
Bile Acids and Salts
03 medical and health sciences
Double-Blind Method
Diabetes mellitus
medicine
Animals
Germ-Free Life
Humans
Hypoglycemic Agents
Microbiome
nutritional and metabolic diseases
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Glucose Tolerance Test
medicine.disease
biology.organism_classification
Fatty Acids, Volatile
type ii diabetes
metformine
030104 developmental biology
Diabetes Mellitus, Type 2
Metagenomics
Subjects
Details
- Language :
- English
- ISSN :
- 10788956 and 17447933
- Database :
- OpenAIRE
- Journal :
- Nature Medicine, Nature Medicine, Nature Publishing Group, 2017, 23 (7), pp.850-858. ⟨10.1038/nm.4345⟩
- Accession number :
- edsair.doi.dedup.....6e9b2960dbcec5f47e566873146de042