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Designing Ecofriendly Bionanocomposite Assembly with Improved Antimicrobial and Potent on-site Zika Virus Vector Larvicidal Activities with its Mode of Action
- Source :
- Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017), Scientific Reports, SCIENTIFIC REPORTS(7)
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group, 2017.
-
Abstract
- Dialyzed natural polymer, fibroin, from Bombyx mori was used to synthesize biocompatible silver and gold nanoparticles in-situ in dispersion form. The films of pure fibroin (PF), fibroin-silver nanocomposite (FSNC) and fibroin-gold nanocomposite (FGNC) were fabricated by drop casting method. The characterization of the resultant dispersion and films was performed by visual color change, UV-Vis spectroscopy and atomic force microscopy. The dispersions of PF, FSNC and FGNC were tested for antibacterial activity against E. coli NCIM 2065, S. aureus NCIM 5021, K. pneumoniae NCIM 2957, P. aeruginosa ATCC 9027 and antifungal activity against A. fumigatus NCIM 902. FSNC dispersion exhibited an effective antimicrobial action against all the tested microbes as compared to FGNC dispersion. The mechanism of action for FSNC and FGNC against these microorganisms is proposed. Additionally, the larvicidal activity of the films was investigated against the larvae of Aedes aegypti. The films of FSNC exhibited 100% mortality while the films of FGNC revealed 86–98% mortality against all the larval instars and pupae of A. aegypti. The phytotoxicity study of the nanocomposite films was also carried out to confirm the reusability of water. This is first noble metal nanocomposite based report on larvicidal activity of zika virus vector.
- Subjects :
- 0301 basic medicine
Insecticides
Staphylococcus aureus
Antifungal Agents
Silver
Metal Nanoparticles
Fibroin
lcsh:Medicine
Mosquito Vectors
02 engineering and technology
Aedes aegypti
Article
Nanocomposites
Microbiology
03 medical and health sciences
Aedes
Escherichia coli
Animals
Mode of action
lcsh:Science
Triticum
Multidisciplinary
Nanocomposite
biology
Zika Virus Infection
Chemistry
Aspergillus fumigatus
fungi
lcsh:R
Zika Virus
021001 nanoscience & nanotechnology
Antimicrobial
biology.organism_classification
Anti-Bacterial Agents
Klebsiella pneumoniae
030104 developmental biology
Colloidal gold
Larva
Pseudomonas aeruginosa
lcsh:Q
Gold
0210 nano-technology
Antibacterial activity
Dispersion (chemistry)
Nuclear chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....6ea1081af248c4a55bd16b2a4f7842e7