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Metabolic relevance for N-hydroxy l-arginine reduction in estrogen-negative breast cancer cells
- Source :
- Amino Acids. 50:1629-1636
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- We had shown Nw-hydroxy-l-arginine (NOHA) as a promising blood-based biomarker for estrogen-receptor-negative (ER−) breast cancer (BC) that differentiates ER− BC based on grade and molecular phenotype. In this in vitro study, we assessed the metabolic relevance for ER− BC-specific NOHA modulation and correlated them with NOHA regulatory responses. This study aids future NOHA clinical utility in ER− BC diagnosis and therapy management and would prove useful for potential drug discovery and development process.
- Subjects :
- 0301 basic medicine
Arginine
medicine.drug_class
Clinical Biochemistry
Breast Neoplasms
Proteomics
Biochemistry
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Breast cancer
Cell Line, Tumor
Humans
Medicine
business.industry
Drug discovery
Organic Chemistry
Estrogens
medicine.disease
030104 developmental biology
Receptors, Estrogen
chemistry
Estrogen
030220 oncology & carcinogenesis
MCF-7 Cells
Cancer research
Biomarker (medicine)
Female
Breast cancer cells
business
Subjects
Details
- ISSN :
- 14382199 and 09394451
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Amino Acids
- Accession number :
- edsair.doi.dedup.....6eb98d19099f96cb86ab9a508236350d
- Full Text :
- https://doi.org/10.1007/s00726-018-2603-x