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Metabolic relevance for N-hydroxy l-arginine reduction in estrogen-negative breast cancer cells

Authors :
Cathy Ng
Srinidi Mohan
Seema Patel
Lisa Harding
Ian Greenstein
Kelly Frazier
Giang Thi Tuyet Nguyen
David Barlow
Source :
Amino Acids. 50:1629-1636
Publication Year :
2018
Publisher :
Springer Science and Business Media LLC, 2018.

Abstract

We had shown Nw-hydroxy-l-arginine (NOHA) as a promising blood-based biomarker for estrogen-receptor-negative (ER−) breast cancer (BC) that differentiates ER− BC based on grade and molecular phenotype. In this in vitro study, we assessed the metabolic relevance for ER− BC-specific NOHA modulation and correlated them with NOHA regulatory responses. This study aids future NOHA clinical utility in ER− BC diagnosis and therapy management and would prove useful for potential drug discovery and development process.

Details

ISSN :
14382199 and 09394451
Volume :
50
Database :
OpenAIRE
Journal :
Amino Acids
Accession number :
edsair.doi.dedup.....6eb98d19099f96cb86ab9a508236350d
Full Text :
https://doi.org/10.1007/s00726-018-2603-x