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Rapid hematoma growth triggers spreading depolarizations in experimental intracortical hemorrhage

Authors :
Andreia Morais
Kazutaka Sugimoto
Carlos A Gómez
Tao Qin
Paul Fischer
Tsubasa Takizawa
Matthias Endres
Mohammad A. Yaseen
Isra Tamim
Sava Sakadzic
Frieder Schlunk
Cenk Ayata
David Y. Chung
Source :
J Cereb Blood Flow Metab, Journal of cerebral blood flow & metabolism 41(6), 1264-1276 (2021). doi:10.1177/0271678X20951993
Publication Year :
2020
Publisher :
SAGE Publications, 2020.

Abstract

Recurrent waves of spreading depolarization (SD) occur in brain injury and are thought to affect outcomes. What triggers SD in intracerebral hemorrhage is poorly understood. We employed intrinsic optical signaling, laser speckle flowmetry, and electrocorticography to elucidate the mechanisms triggering SD in a collagenase model of intracortical hemorrhage in mice. Hematoma growth, SD occurrence, and cortical blood flow changes were tracked. During early hemorrhage (0–4 h), 17 out of 38 mice developed SDs, which always originated from the hematoma. No SD was detected at late time points (8–52 h). Neither hematoma size, nor peri-hematoma perfusion were associated with SD occurrence. Further, arguing against ischemia as a trigger factor, normobaric hyperoxia did not inhibit SD occurrence. Instead, SDs always occurred during periods of rapid hematoma growth, which was two-fold faster immediately preceding an SD compared with the peak growth rates in animals that did not develop any SDs. Induced hypertension accelerated hematoma growth and resulted in a four-fold increase in SD occurrence compared with normotensive animals. Altogether, our data suggest that spontaneous SDs in this intracortical hemorrhage model are triggered by the mechanical distortion of tissue by rapidly growing hematomas.

Details

ISSN :
15597016 and 0271678X
Volume :
41
Database :
OpenAIRE
Journal :
Journal of Cerebral Blood Flow & Metabolism
Accession number :
edsair.doi.dedup.....6ebeb4decbb1f839cfc6d8325043f2ef
Full Text :
https://doi.org/10.1177/0271678x20951993