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Synthesis of imidazo[1,2-c]thiazoles through Pd-catalyzed bicyclization of tert-butyl isonitrile with thioamides
- Source :
- Organic & Biomolecular Chemistry. 17:8403-8407
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- Building new biological molecules is challenging. Herein, imidazo[1,2-c]thiazoles were synthesized as a new class of heterobicyclic analogs through Pd-catalyzed cascade bicyclization from isonitriles with thioamides. The bicyclic scaffolds were constructed by inserting three molecules of isonitrile into two molecules of thioamide and then cyclizing them in a one-pot procedure. In vitro antitumor studies of these new compounds were conducted by using the MTT assay, and compound 3c showed excellent inhibitory effects against HepG2 at 7.06 ± 0.68 μM.
- Subjects :
- chemistry.chemical_classification
Tert butyl
Bicyclic molecule
010405 organic chemistry
Chemistry
Biomolecule
Organic Chemistry
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
In vitro
0104 chemical sciences
Catalysis
Molecule
MTT assay
Physical and Theoretical Chemistry
Thioamide
Subjects
Details
- ISSN :
- 14770539 and 14770520
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Organic & Biomolecular Chemistry
- Accession number :
- edsair.doi.dedup.....6ed14cc44047d259ed66ce50b2c0df12