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Mn(<scp>ii</scp>) chelate-coated superparamagnetic iron oxide nanocrystals as high-efficiency magnetic resonance imaging contrast agents
- Source :
- Nanoscale Advances. 2:2752-2757
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- In this communication, a paramagnetic bifunctional manganese(II) chelate ([Mn(Dopa-EDTA)]2−) containing a catechol group is designed and synthesized. The catechol can bind iron ions on the surface of superparamagnetic iron oxide (SPIO) nanocrystals to form core–shell nanoparticles. Both 4 and 7 nm SPIO@[Mn(Dopa-EDTA)]2− show good water solubility, single-crystal dispersion, and low cytotoxicity. The study of the interplay between the longitudinal and transverse relaxation revealed that 4 nm SPIO@[Mn(Dopa-EDTA)]2− with lower r2/r1 = 1.75 at 0.5 T tends to be a perfect T1 contrast agent while 7 nm SPIO@[Mn(Dopa-EDTA)]2− with a higher r2/r1 = 15.0 at 3.0 T tends to be a T2 contrast agent. Interestingly, 4 nm SPIO@[Mn(Dopa-EDTA)]2− with an intermediate value of r2/r1 = 5.26 at 3.0 T could act as T1–T2 dual-modal contrast agent. In vivo imaging with the 4 nm SPIO@[Mn(Dopa-EDTA)]2− nanoparticle shows unique imaging features: (1) long-acting vascular imaging and different signal intensity changes between the liver parenchyma and blood vessels with the CEMRA sequence; (2) the synergistic contrast enhancement of hepatic imaging with the T1WI and T2WI sequence. In summary, these Fe/Mn hybrid core–shell nanoparticles, with their ease of synthesis, good biocompatibility, and synergistic contrast enhancement ability, may provide a useful method for tissue and vascular MR imaging.
- Subjects :
- Catechol
Materials science
Biocompatibility
General Engineering
Nanoparticle
chemistry.chemical_element
Bioengineering
02 engineering and technology
General Chemistry
Manganese
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Atomic and Molecular Physics, and Optics
0104 chemical sciences
chemistry.chemical_compound
Paramagnetism
chemistry
General Materials Science
Chelation
0210 nano-technology
Bifunctional
Preclinical imaging
Nuclear chemistry
Subjects
Details
- ISSN :
- 25160230
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Nanoscale Advances
- Accession number :
- edsair.doi.dedup.....6ed16d7eca6c4664c2bd88e38e362ad0