Additional file 1 of TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer

Additional file 1: Fig. S1. WTP53 is required to trigger abscopal effects after irradiation. Fig. S2. A549sip53 cells grown as 3D models did not show irradiation-induced SASP; A549 cells grown as monolayer and exposed to IR A549sip53 EVs did not show expression of DNA:RNA hybrid structures; DNA:RNA ORF1 co-localization analysis in A549sip53 after irradiation exposure. Fig. S3. EVs secreted by irradiated A549 induce M1 polarization in a human macrophage cell line. Fig. S4. Analysis of DNA damage and growth rate in A549 and A549sip53 cells exposed to irradiation doses of 10 Gy or 20 Gy.