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Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model
- Source :
- Retrovirology, 10, Retrovirology
- Publication Year :
- 2013
-
Abstract
- Transformation by the Tax oncoprotein of the human T cell leukemia virus type 1 (HTLV-1) is governed by actions on cellular regulatory signals, including modulation of specific cellular gene expression via activation of signaling pathways, acceleration of cell cycle progression via stimulation of cyclin-dependent kinase activity leading to retinoblastoma protein (pRb) hyperphosphorylation and perturbation of survival signals. These actions control early steps in T cell transformation and development of Adult T cell leukemia (ATL), an aggressive malignancy of HTLV-1 infected T lymphocytes. Post-translational modifications of Tax by phosphorylation, ubiquitination, sumoylation and acetylation have been implicated in Tax-mediated activation of the NF-κB pathway, a key function associated with Tax transforming potential.<br />Journal Article<br />Research Support, Non-U.S. Gov't<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published
- Subjects :
- Gene Products, tax -- metabolism
CDK4
Fibroblasts -- virology
Human T-lymphotropic virus 1 -- pathogenicity
Lysine -- metabolism
Tax
SUMO protein
P300-CBP Transcription Factors
Histone Deacetylases
p300-CBP Transcription Factors -- metabolism
Transformation
Cell Line
Ubiquitin
Virology
Animals
Humans
p300-CBP Transcription Factors
Kinase activity
Human T-lymphotropic virus 1
Histone deacetylase 5
Leukemia
biology
Physiologie de la régulation
Research
Lysine
Retinoblastoma protein
Virologie médicale
Acetylation
Gene Products, tax
Fibroblasts
Sciences bio-médicales et agricoles
Cell Transformation, Viral
Cell biology
Rats
Infectious Diseases
HTLV-1
Immunology
biology.protein
Phosphorylation
Histone Deacetylases -- metabolism
Protein Processing, Post-Translational
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Retrovirology, 10, Retrovirology
- Accession number :
- edsair.doi.dedup.....6ee701f71482c8e8e3732ac7a311293e