Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences

Human papillomavirus 11 (HPV11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic HPV vaccines. We established the largest collection of globally circulating HPV11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (CGs) from six continents. The genomic variation within the 2,800-bp E5a-E5b-L1-upstream regulatory region was initially studied in 181/207 (87.4%) HPV11 isolates collected for this study. Of these, the CGs of 30 HPV11 variants containing unique single nucleotide polymorphisms (SNPs), indels (insertions or deletions), or amino acid changes were fully sequenced. A maximum likelihood tree based on the global alignment of 78 HPV11 CGs (30 CGs from our study and 48 CGs from GenBank) revealed two HPV11 lineages (lineages A and B) and four sublineages (sublineages A1, A2, A3, and A4). HPV11 (sub)lineage-specific SNPs within the CG were identified, as well as the 208-bp representative region for CG-based phylogenetic clustering within the partial E2 open reading frame and noncoding region 2. Globally, sublineage A2 was the most prevalent, followed by sublineages A1, A3, and A4 and lineage B. Fil: Jelen, Mateja M.. University Of Ljubljana. Faculty of Medicine. Institute Of Pathology; Argentina Fil: Chen, Zigui. Prince Of Wales Hospital Hong Kong; Hong Kong Fil: Kocjan, Boštjan J.. University Of Ljubljana. Faculty Of Medicine; Eslovenia Fil: Hošnjak, Lea. University Of Ljubljana. Faculty Of Medicine; Eslovenia Fil: Burt, Felicity J.. University Of The Free State. School Of Medicine; Sudáfrica Fil: Chan, Paul K.S.. Prince Of Wales Hospital Hong Kong; Hong Kong Fil: Chouhy, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina Fil: Combrinck, Catharina E.. University Of The Free State. School Of Medicine; Sudáfrica Fil: Estrade, Christine. University of Lausanne; Suiza Fil: Fiander, Alison. Cardiff University; Reino Unido Fil: Garland, Suzanne M.. Royal Women's Hospital, Carlton; Australia. Murdoch Children's Research Institute; Australia. University of Melbourne; Australia Fil: Giri, Adriana Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina Fil: González, Joaquín Víctor. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina Fil: Gröning, Arndt. Medizinisches Versorgungszentrum Wagnerstibbe Für Laboratoriumsmedizin Und Pathologie; Alemania Fil: Hibbitts, Sam. Cardiff University; Reino Unido Fil: Luk, Tommy N.M.. Prince Of Wales Hospital Hong Kong; Hong Kong. Centre For Health Protection; Hong Kong Fil: Marinic, Karina. Dr. Julio C. Perrando Hospital; Argentina Fil: Matsukura, Toshihiko. Momate Memorial Laboratory; Japón Fil: Neumann, Anna. Medizinisches Versorgungszentrum Wagnerstibbe Für Laboratoriumsmedizin Und Pathologie; Alemania Fil: Oštrbenk, Anja. University Of Ljubljana. Faculty Of Medicine; Eslovenia Fil: Picconi, Maria Alejandra. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina Fil: Sagadin, Martin. University Of Ljubljana. Faculty Of Medicine; Eslovenia Fil: Sahli, Roland. University of Lausanne; Suiza Fil: Seedat, Riaz Y.. University Of The Free State. School Of Medicine; Sudáfrica Fil: Seme, Katja. University Of Ljubljana. Faculty Of Medicine; Eslovenia Fil: Severini, Alberto. National Microbiology Laboratory; Canadá Fil: Sinchi, Jessica L.. Dr. Julio C. Perrando Hospital; Argentina Fil: Smahelova, Jana. Institute Of Hematology And Blood Transfusion; República Checa Fil: Tabrizi, Sepehr N.. Royal Women's Hospital, Carlton; Australia. University of Melbourne; Australia. Murdoch Children's Research Institute; Australia Fil: Tachezy, Ruth. Institute Of Hematology And Blood Transfusion; República Checa Fil: Faybush, Sarah Tohme. National Microbiology Laboratory; Canadá Fil: Uloza, Virgilijus. Lithuanian University Of Health Sciences; Lituania Fil: Uloziene, Ingrida. Lithuanian University Of Health Sciences; Lituania Fil: Wong, Yong Wee. Universiti Kebangsaan Malaysia; Malasia Fil: Lepej,Snježana Židovec. University Of Zagreb. School Of Medicine; Croacia Fil: Burk, Robert D.. Albert Einstein College Of Medicine Of Yeshiva University; Estados Unidos Fil: Poljak, Mario. University Of Ljubljana. Faculty Of Medicine; Eslovenia