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Effect of Canagliflozin on Renal and Cardiovascular Outcomes across Different Levels of Albuminuria
- Source :
- J Am Soc Nephrol, Journal of the American Society of Nephrology, 30(11), 2229-2242. AMER SOC NEPHROLOGY
- Publication Year :
- 2019
- Publisher :
- AMER SOC NEPHROLOGY, 2019.
-
Abstract
- BACKGROUND: If SGLT2 inhibitors protect the kidneys by reducing albuminuria as hypothesized, people with type 2 diabetes mellitus (T2DM) with higher albuminuria should benefit more. METHODS: We conducted a post-hoc analysis of data from the CANagliflozin cardioVascular Assessment Study (CANVAS) Program, which randomized 10,142 participants with T2DM and high cardiovascular risk to canagliflozin or placebo. We assessed effects of canagliflozin on renal, cardiovascular, and safety outcomes by baseline albuminuria. The trial included 2266 participants (22.3%) with moderately increased albuminuria (urinary albumin/creatinine ratio [UACR] 30–300 mg/g) and 760 (7.5%) with severely increased albuminuria (UACR >300 mg/g) at baseline. RESULTS: Canagliflozin lowered albuminuria with greater proportional reductions in those with moderately and severely increased albuminuria (P heterogeneity
- Subjects :
- Male
CHRONIC KIDNEY-DISEASE
endocrine system diseases
urologic and male genital diseases
Cardiovascular System
GLOMERULAR-FILTRATION-RATE
chemistry.chemical_compound
INSUFFICIENCY
canagliflozin
Canagliflozin
RISK
cardiovascular
EMPAGLIFLOZIN
Absolute risk reduction
SGLT2 inhibitor
General Medicine
Urology & Nephrology
Middle Aged
female genital diseases and pregnancy complications
Nephrology
Female
medicine.symptom
Glomerular Filtration Rate
medicine.drug
medicine.medical_specialty
Urology
INHIBITION
Renal function
TYPE-2 DIABETES-MELLITUS
albuminuria
Clinical Research
medicine
Empagliflozin
Humans
Sodium-Glucose Transporter 2 Inhibitors
Aged
Creatinine
urogenital system
business.industry
MICROALBUMINURIA
Type 2 Diabetes Mellitus
1103 Clinical Sciences
medicine.disease
Diabetes Mellitus, Type 2
chemistry
COLLABORATIVE METAANALYSIS
Albuminuria
Microalbuminuria
renal
business
Subjects
Details
- Language :
- English
- ISSN :
- 15333450 and 10466673
- Volume :
- 30
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of the American Society of Nephrology
- Accession number :
- edsair.doi.dedup.....6eec378b34840d98ea7429d3c9edde26