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Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer
- Source :
- Journal of cellular biochemistryREFERENCES. 121(4)
- Publication Year :
- 2019
-
Abstract
- Breast cancer (BC) and prostate cancer (PC) are the second most common malignant tumors in women and men in western countries, respectively. The risks of death are 14% for BC and 9% for PC. Abnormal estrogen and androgen levels are related to carcinogenesis of the breast and prostate. Estradiol stimulates cancer development in BC. The effect of estrogen on PC is concentration-dependent, and estrogen can regulate androgen production, further affecting PC. Estrogen can also increase the risk of androgen-induced PC. Androgen has dual effects on BC via different metabolic pathways, and the role of the androgen receptor (AR) in BC also depends on cell subtype and downstream target genes. Androgen and AR can stimulate both primary PC and castration-resistant PC. Understanding the mechanisms of the effects of estrogen and androgen on BC and PC may help us to improve curative BC and PC treatment strategies.
- Subjects :
- 0301 basic medicine
Male
Risk
medicine.drug_class
Cell
Breast Neoplasms
urologic and male genital diseases
medicine.disease_cause
Biochemistry
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Breast cancer
Prostate
Cell Line, Tumor
Medicine
Animals
Humans
Phosphorylation
Molecular Biology
Dose-Response Relationship, Drug
Estradiol
business.industry
Prostatic Neoplasms
Estrogens
Cell Biology
Androgen
medicine.disease
3. Good health
Androgen receptor
Gene Expression Regulation, Neoplastic
030104 developmental biology
medicine.anatomical_structure
Receptors, Estrogen
Estrogen
Receptors, Androgen
030220 oncology & carcinogenesis
Cancer research
Androgens
Female
business
Carcinogenesis
Signal Transduction
Subjects
Details
- ISSN :
- 10974644
- Volume :
- 121
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of cellular biochemistryREFERENCES
- Accession number :
- edsair.doi.dedup.....6ef09c40c78060480e7c73d9fa1169e5