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A Lanthanide Upconversion Nanothermometer for Precise Temperature Mapping on Immune Cell Membrane

A Lanthanide Upconversion Nanothermometer for Precise Temperature Mapping on Immune Cell Membrane

Authors :
Hanyu Liang
Kaidong Yang
Yating Yang
Zhongzhu Hong
Shihua Li
Qiushui Chen
Juan Li
Xiaorong Song
Huanghao Yang
Source :
Nano letters. 22(22)
Publication Year :
2022

Abstract

Cell temperature monitoring is of great importance to uncover temperature-dependent intracellular events and regulate cellular functions. However, it remains a great challenge to precisely probe the localized temperature status in living cells. Herein, we report a strategy for in situ temperature mapping on an immune cell membrane for the first time, which was achieved by using the lanthanide-doped upconversion nanoparticles. The nanothermometer was designed to label the cell membrane by combining metabolic labeling and click chemistry and can leverage ratiometric upconversion luminescence signals to in situ sensitively monitor temperature variation (1.4% K

Details

ISSN :
15306992
Volume :
22
Issue :
22
Database :
OpenAIRE
Journal :
Nano letters
Accession number :
edsair.doi.dedup.....6f0232f365eefc039bba42f88cc92434