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External validation of a prognostic model based on total tumor load of sentinel lymph node for early breast cancer patients

Authors :
Ana Calatrava-Fons
Antonio Piñero-Madrona
Francisco Ripoll-Orts
J.I. Sánchez-Méndez
Salomón Menjón-Beltrán
Asunción Chaves-Benito
Maximiliano Rodrigo Gómez-de la Bárcena
Vicente Peg-Cámara
UAM. Departamento de Obstetricia y Ginecología
Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)
Source :
Breast Cancer Research and Treatment, Biblos-e Archivo: Repositorio Institucional de la UAM, Universidad Autónoma de Madrid, Biblos-e Archivo. Repositorio Institucional de la UAM, instname, BREAST CANCER RESEARCH AND TREATMENT, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Publication Year :
2020

Abstract

Background: A prognostic model based on the results of molecular analysis of sentinel lymph nodes (SLN) is needed to replace the information that staging the entire axilla provided. The aim of the study is to conduct an external validation of a previously developed model for the prediction of 5-year DFS in a group of breast cancer patients that had undergone SLN biopsy assessed by the One Step Nucleic Acid Amplification (OSNA) method. Methods: We collected retrospective data of 889 patients with breast cancer, who had not received systemic treatment before surgery, and who underwent SLN biopsy and evaluation of all SLN by OSNA. The discrimination ability of the model was assessed by the area under the ROC curve (AUC ROC), and its calibration by comparing 5-years DFS Kaplan–Meier estimates in quartile groups of model predicted probabilities (MPP). Results: The AUC ROC ranged from 0.78 (at 2 years) to 0.73 (at 5 years) in the training set, and from 0.78 to 0.71, respectively, in the validation set. The MPP allowed to distinguish four groups of patients with heterogeneous DFS (log-rank test p < 0.0001). In the highest risk group, the HR were 6.04 [95% CI 2.70, 13.48] in the training set and 4.79 [2.310, 9.93] in the validation set. Conclusions: The model for the prediction of 5-year DFS was successfully validated using the most stringent form of validation, in centers different from those involved in the development of the model. The external validation of the model confirms its utility for the prediction of 5-year DFS and the usefulness of the TTL value as a prognostic variable.<br />This study was supported by Sysmex España S.L.

Details

Language :
English
ISSN :
01676806
Database :
OpenAIRE
Journal :
Breast Cancer Research and Treatment, Biblos-e Archivo: Repositorio Institucional de la UAM, Universidad Autónoma de Madrid, Biblos-e Archivo. Repositorio Institucional de la UAM, instname, BREAST CANCER RESEARCH AND TREATMENT, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Accession number :
edsair.doi.dedup.....6f192d57262c31ed256dc41465d53898